Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name biphenyl
CAS 1,1′-biphenyl

Reference List

PubMed Abstract RScore(About this table)
19651242 Park H, Ahn IY, Kim H, Lee J, Shin SC: Glutathione S-transferase as a biomarker in the Antarctic bivalve Laternula elliptica after exposure to the polychlorinated biphenyl mixture Aroclor 1254. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Nov;150(4):528-36. Epub 2009 Aug 7.
7(0,0,1,2) Details
19410653 Feng X, Singh BR: Molecular identification of glutathione S-transferase gene and cDNAs of two isotypes from northern quahog (Mercenaria mercenaria). Comp Biochem Physiol B Biochem Mol Biol. 2009 Sep;154(1):25-36. Epub 2009 May 3.

These results suggest that GST Pi-1 and Pi-2 from the northern quahog belong to the Pi class GSTs which may be involved in polychlorinated biphenyl (PCB) dechlorination.
3(0,0,0,3) Details
18502095 Murugesan P, Muthusamy T, Balasubramanian K, Arunakaran J: Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells. Reprod Toxicol. 2008 Aug;25(4):447-54. Epub 2008 Apr 18.

In addition, Leydig cellular enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), gamma-glutamyl transpeptidase (gamma-GT), glutathione-S-transferase (GST) and non-enzymatic antioxidants such as vitamin C and E were assayed.
1(0,0,0,1) Details
19445841 Ozdemir S, Tandogan B, Ulusu NN, Turan B: Angiotensin II receptor blockage prevents diabetes-induced oxidative damage in rat heart. Folia Biol. 2009;55(1):11-6.


In this study we aimed to investigate the effect of angiotensin II type 1 (AT1) receptor blockage on some antioxidant enzymes such as glucose- 6-phosphate dehydrogenase (G6PD), 6-phoshogluconate dehydrogenase (6PGD), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px), and catalase (CAT) in the heart of streptozotocin (STZ)-induced diabetic rats.
1(0,0,0,1) Details
18273903 Sinha M, Manna P, Sil PC: Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain. J Biochem Mol Toxicol. 2008 Feb;22(1):15-26.


Oral administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly decreased the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase, the level of cellular metabolites, reduced glutathione, total thiols and increased the level of oxidized glutathione.
1(0,0,0,1) Details
17967502 Saito J, Shibuya K, Nagase H: Anti-clastogenic effect of magnolol on benzo (a) pyrene-induced clastogenicity in mice. Food Chem Toxicol. 2008 Feb;46(2):694-700. Epub 2007 Sep 26.


In order to elucidate the mechanism behind this effect, we measured the activity of the detoxifying enzymes [UDP-glucuronosyltransferase (UGT) and glutathione-S-transferase (GST)] and antioxidative enzymes [superoxide dismutase (SOD) and catalase] in the liver when treated with an oral administration of magnolol at various administration times.
1(0,0,0,1) Details
17910617 Manna P, Sinha M, Sil PC: Protection of arsenic-induced hepatic disorder by arjunolic acid. Basic Clin Pharmacol Toxicol. 2007 Nov;101(5):333-8.


Administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly reduced the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione S-transferase, glutathione reductase and glutathione peroxidase as well as depleted the level of reduced glutathione and total thiols.
1(0,0,0,1) Details