| Name | CYP1A1 |
|---|---|
| Synonyms | AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20163825 | Yordy JE, Wells RS, Balmer BC, Schwacke LH, Rowles TK, Kucklick JR: Life history as a source of variation for persistent organic pollutant (POP) patterns in a community of common bottlenose dolphins (Tursiops truncatus) resident to Sarasota Bay, FL. Sci Total Environ. 2010 Apr 1;408(9):2163-72. Epub 2010 Feb 16. To assess the variation of POP mixtures that occurs among individuals of a population, polychlorinated biphenyl (PCB), organochlorine pesticide (OCP) and polybrominated diphenyl ether (PBDE) concentrations were measured in blubber and milk of bottlenose dolphins resident to Sarasota Bay, FL, and principal components analysis (PCA) was used to explain mixture variations in relation to age, sex and reproductive maturity. Metabolically-refractory PCBs significantly increased with age in male dolphins, whereas PCBs subject to cytochrome p450 1A1 metabolism did not, suggesting that changes in male POP patterns likely resulted from the selective accumulation of persistent POP congeners. |
1(0,0,0,1) | Details |
| 18178546 | Silkworth JB, Carlson EA, McCulloch C, Illouz K, Goodwin S, Sutter TR: Toxicogenomic analysis of gender, chemical, and dose effects in livers of TCDD- or aroclor 1254-exposed rats using a multifactor linear model. Toxicol Sci. 2008 Apr;102(2):291-309. Epub 2008 Jan 3. The relative potency of dioxins and polychlorinated biphenyl mixtures, such as Aroclor 1254, is often estimated using the internationally endorsed toxic equivalency (TEQ) approach. The known aryl hydrocarbon receptor (AHR) battery genes (Cyp1a1, Cyp1a2, Cyp1b1, Aldh3a1), and novel genes, responded in a TEQ dose-dependent manner in both genders. |
1(0,0,0,1) | Details |
| 18786521 | Lim EJ, Majkova Z, Xu S, Bachas L, Arzuaga X, Smart E, Tseng MT, Toborek M, Hennig B: Coplanar polychlorinated biphenyl-induced CYP1A1 is regulated through caveolae signaling in vascular endothelial cells. Chem Biol Interact. 2008 Nov 25;176(2-3):71-8. Epub 2008 Aug 22. |
9(0,0,1,4) | Details |
| 18953099 | Ptak A, Ludewig G, Gregoraszczuk EL: A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary. J Physiol Pharmacol. 2008 Sep;59(3):577-88. |
7(0,0,1,2) | Details |
| 19571387 | Saito J, Fukushima H, Nagase H: Anti-clastogenic effect of magnolol-containing Hange-koboku-to, Dai-joki-to, Goshaku-san, and Magnoliae Cortex on benzo (a) pyrene-induced clastogenicity in mice. Biol Pharm Bull. 2009 Jul;32(7):1209-14. The anti-clastogenic mechanisms employed by the kampo medicines and Magnoliae Cortex were also investigated by evaluating in vivo CYP1A1 activity using the zoxazolamine paralysis test. |
3(0,0,0,3) | Details |
| 18092871 | Yang F, Xu Y, Pan H, Wu D: Induction of hepatic cytochrome P4501A1/2B activity and disruption of thyroglobulin synthesis/secretion by mono-ortho polychlorinated biphenyl and its hydroxylated metabolites in rat cell lines. Environ Toxicol Chem. 2008 Jan;27(1):220-5. In this study, mono-ortho PCB 156 and its hydroxylated metabolites 4'-OH-PCB 159, 4'-OH-PCB 121, and 4'-OH-PCB 72 were selected to investigate the toxic effects on rat hepatoma H4IIE cell line and rat thyroid follicle FRTL-5 cell line at concentrations of 1, 10 (2), 10 (4) nM. 7-Ethoxyresorufin-O-deethylase (EROD) and 7-pentoxyresorufin-O-dealkylase (PROD) activities were determined with micro-EROD/PROD to indicate cytochrome P4501A1 (CYP1A1) and cytochrome P4502B (CYP2B) induction in the H4IIE cell after exposure for 72 h. |
2(0,0,0,2) | Details |
| 19616879 | Hansson MC, Persson ME, Larsson P, von Schantz T: Polychlorinated biphenyl (PCB) load, lipid reserves and biotransformation activity in migrating Atlantic salmon from River Morrum, Sweden. Environ Pollut. 2009 Dec;157(12):3396-403. Epub 2009 Jul 18. For these analyses we sampled adult Atlantic salmon during migration in the Swedish River Morrum and measured the 21 most common PCB congeners ( summation operatorPCB) and lipid levels in muscle tissue, aryl hydrocarbon receptor (AHR2) and cytochrome P4501A1 (CYP1A1) transcript levels as well as ethoxyresorufin-O-deethylase activity (EROD) in liver. |
2(0,0,0,2) | Details |
| 19692669 | Carlson EA, McCulloch C, Koganti A, Goodwin SB, Sutter TR, Silkworth JB: Divergent transcriptomic responses to aryl hydrocarbon receptor agonists between rat and human primary hepatocytes. Toxicol Sci. 2009 Nov;112(1):257-72. Epub 2009 Aug 19. This study employed toxicogenomic technology to reveal species differences in response to two prototypical aryl hydrocarbon receptor (AHR) agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin and the polychlorinated biphenyl (PCB) congener PCB 126. This observed insensitivity of human cells to PCB 126 is consistent with more traditional measurements of AHR activation (i.e., cytochrome P450 1A1 enzyme activity) and suggests that the species difference in PCB 126 sensitivity is likely due to certain aspects of AHR function. |
1(0,0,0,1) | Details |