| Name | 5 HT 1A |
|---|---|
| Synonyms | 5 HT 1A; serotonin receptor; 5 HT1A; 5 hydroxytryptamine (serotonin) receptor 1A; 5 hydroxytryptamine 1A receptor; 5HT1A; ADRB2RL1; ADRBRL 1… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17880377 | Garcia M, Moran A, Martin ML, Ortizde Urbina AV, San Roman L: Diabetes-induced changes in modulation of vagally-induced bradycardia in rat heart. Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1199-206. Enhancement of the vagally induced bradycardia elicited by low doses of 5-CT was reproduced by the selective 5-HT (1A) receptor agonist 8-hydroxydipropylaminotretalin hydrobromide (8-OH-DPAT; 50 microg/kg). |
2(0,0,0,2) | Details |
| 18027904 | Ortar G, Cascio MG, De Petrocellis L, Morera E, Rossi F, Schiano-Moriello A, Nalli M, de Novellis V, Woodward DF, Maione S, Di Marzo V: New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. J Med Chem. 2007 Dec 27;50(26):6554-69. Epub 2007 Nov 21. N-arachidonoylserotonin (AA-5-HT, 1a) is an inhibitor of fatty acid amide hydrolase (FAAH) that acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels and is analgesic in rodents. |
1(0,0,0,1) | Details |
| 19217900 | Tadori Y, Forbes RA, McQuade RD, Kikuchi T: Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors. Eur J Pharmacol. 2009 Apr 1;607(1-3):35-40. Epub 2009 Feb 13. In an effort to elucidate aripiprazole's pharmacological activity in relation to clinically relevant fluctuation of D (2) receptor reserves, we compared the properties of to other antipsychotics, clozapine, ziprasidone, and haloperidol, a D (2) receptor partial agonist, bifeprunox, D (3) receptor modulators, BP897 (N-[4-[4-(2-Methoxyphenyl)-1-piperazinyl] butyl] naphthalene-2-carboxamide) and GR103691 (4'-Acetyl-N-[4-[4-(2-methoxyphenyl) piperazin-1-yl] butyl] biphenyl-4-carbox amide), and a 5-HT (1A) partial agonist, using forskolin-stimulated cAMP accumulation in clonal Chinese hamster ovary cell lines expressing low and high densities of human D (2S) receptors (hD (2S)-Low and hD (2S)-High, respectively). |
31(0,1,1,1) | Details |
| 18930727 | Haddjeri N, Blier P: Neurokinin-1 receptor antagonists modulate brain and interactions. Eur J Pharmacol. 2008 Dec 14;600(1-3):64-70. Epub 2008 Oct 9. While acute administration of the tachykinin NK1 receptor antagonist CP-96,345 (10 mg/kg, i.p.) attenuated the responsiveness of dorsal raphe 5-HT (1A) autoreceptors, lesioning neurons with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) prevented the enhancing action of a 2-day treatment with CP-96,345 on neuronal firing, suggesting that tachykinin NK1 receptor antagonists influence system via neurons independently of their firing rate. |
1(0,0,0,1) | Details |