Protein Information

Name Lipoxygenase (protein family or complex)
Synonyms arachidonate lipoxygenase; arachidonate lipoxygenases; lipoxygenase; lipoxygenases

Compound Information

Name biphenyl
CAS 1,1′-biphenyl

Reference List

PubMed Abstract RScore(About this table)
18536755 Kim HJ, Kim DK, Kim H, Koh JY, Kim KM, Noh MS, Lee S, Kim S, Park SH, Kim JJ, Kim SY, Lee CH: Involvement of the BLT2 receptor in the itch-associated scratching induced by 12-(S)-lipoxygenase products in ICR mice. Br J Pharmacol. 2008 Jul;154(5):1073-8. Epub 2008 Jun 9.

To confirm the involvement of the BLT2 receptor in 12 (S)-HPETE-induced scratching, we studied the scratch response using the BLT2 receptor agonists compound A (4'-[[pentanoyl (phenyl) amino] methyl]-1,1'-biphenyl-2-carboxylic acid) and 12 (S)-HETE (12 (S)-hydroxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid).
2(0,0,0,2) Details
18991744 Maria K, Dimitra HL, Maria G: Synthesis and anti-inflammatory activity of chalcones and related Mannich bases. Med Chem. 2008 Nov;4(6):586-96.


Among the tested compounds 5 and 6 showed the highest lipoxygenase (LO) inhibitory activity.
1(0,0,0,1) Details
19241532 Min B, Nam KC, Cordray J, Ahn DU: Endogenous factors affecting oxidative stability of beef loin, pork loin, and chicken breast and thigh meats. J Food Sci. 2008 Aug;73(6):C439-46.


TBARS values of raw BL, however, significantly increased during 7-d storage because of high heme iron content, high lipoxygenase-like activities, and low 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities.
1(0,0,0,1) Details
19150597 Symeonidis T, Chamilos M, Hadjipavlou-Litina DJ, Kallitsakis M, Litinas KE: Synthesis of hydroxycoumarins and hydroxybenzo [f]- or [h] coumarins as lipid peroxidation inhibitors. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1139-42. Epub 2008 Dec 31.


The compounds were tested in vitro for their ability: (i) to interact with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) stable free radical, (ii) to inhibit lipid peroxidation, (iii) to scavenge the superoxide anion, (iv) to inhibit the activity of soybean lipoxygenase and (v) to inhibit in vivo the carrageenin-induced rat paw edema.
1(0,0,0,1) Details
19551737 Kovala-Demertzi D, Hadjipavlou-Litina D, Primikiri A, Staninska M, Kotoglou C, Demertzis MA: Anti-inflammatory, antiproliferative, and radical-scavenging activities of tolfenamic acid and its metal complexes. Chem Biodivers. 2009 Jun;6(6):948-60.


Their ability to inhibit soybean lipoxygenase, beta-glucuronidase, and trypsin-induced proteolysis was studied.
1(0,0,0,1) Details
19853459 Detsi A, Majdalani M, Kontogiorgis CA, Hadjipavlou-Litina D, Kefalas P: Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. Bioorg Med Chem. 2009 Dec 1;17(23):8073-85. Epub 2009 Oct 6.

2(0,0,0,2) Details
19504389 Ali S, Yasmeen S, Afza N, Malik A, Iqbal L, Lateef M, Riaz N, Ashraf M: Mutiniside, new antioxidant phenolic glucoside from Abutilon muticum. J Asian Nat Prod Res. 2009;11(5):457-64.


Compound 1 showed significant antioxidant activity while moderate inhibitory activity was observed against the enzyme lipoxygenase.
1(0,0,0,1) Details