| Name | NK 1 receptor |
|---|---|
| Synonyms | NK 1 receptor; NK 1R; NK1R; NKIR; Neurokinin 1 receptor; SPR; Substance P Receptor; TAC1R… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18544900 | Watanabe Y, Okamoto M, Ishii T, Takatsuka S, Taniguchi H, Nagasaki M, Saito A: Long-lasting anti-emetic effect of T-2328, a novel NK (1) antagonist. . J Pharmacol Sci. 2008 Jun;107(2):151-8. Epub 2008 Jun 5. The effect of T-2328 {2--4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl] amino] methyl]-[1 ,1'-biphenyl]-4-carbonitrile dihydrochloride}, a novel tachykinin NK (1)-receptor antagonist, was examined on cisplatin-induced emesis in ferrets. |
31(0,1,1,1) | Details |
| 18160487 | Ramnath RD, Sun J, Adhikari S, Zhi L, Bhatia M: Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. Am J Physiol Cell Physiol. 2008 Mar;294(3):C683-92. Epub 2007 Dec 26. Interaction of the neuropeptide substance P (SP) with its high-affinity neurokinin-1 receptor (NK1R) plays an important role in the pathophysiology of acute pancreatitis. |
4(0,0,0,4) | Details |
| 18809416 | Tang HB, Li YS, Miyano K, Nakata Y: Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the -mediated substance P release from cultured rat dorsal root ganglion neurons. Neuropharmacology. 2008 Dec;55(8):1405-11. Epub 2008 Sep 17. |
4(0,0,0,4) | Details |
| 18326823 | Li PC, Chen WC, Chang LC, Lin SC: Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure. Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L912-20. Epub 2008 Mar 7. Rats were pretreated with NK-1 receptor antagonist CP-96345, NK-2 receptor antagonist SR-48968, or catechins. |
2(0,0,0,2) | Details |
| 18602450 | Chen SS, Yang CC, Chien CT: Colorectal distension enforce acute urinary bladder distension-induced hepatic vasoconstriction in the rat. Neurosci Lett. 2008 Oct 10;443(3):257-60. Epub 2008 Jun 27. Hepatic sympathetic denervation and intravenous CP96,345 (neurokinin 1 receptor antagonist) and SR48968 (neurokinin 2 receptor antagonist) were adopted to determine the possible neural pathways in response to AUBD and/or CRD stimulation. |
2(0,0,0,2) | Details |
| 18930727 | Haddjeri N, Blier P: Neurokinin-1 receptor antagonists modulate brain and interactions. Eur J Pharmacol. 2008 Dec 14;600(1-3):64-70. Epub 2008 Oct 9. |
1(0,0,0,1) | Details |
| 18187929 | Watanabe Y, Asai H, Ishii T, Kiuchi S, Okamoto M, Taniguchi H, Nagasaki M, Saito A: Pharmacological characterization of T-2328, 2--4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl] amino] methyl]-[1, 1'-biphenyl]-4-carbonitrile dihydrochloride, as a brain-penetrating antagonist of tachykinin NK1 receptor. J Pharmacol Sci. 2008 Jan;106(1):121-7. Epub 2008 Jan 11. The pharmacological properties of T-2328 were evaluated as an antagonist of the tachykinin neurokinin 1 (NK (1)) receptor. |
1(0,0,0,1) | Details |