| Name | 5 HT1B receptor |
|---|---|
| Synonyms | 5 HT 1B; S12; 5 HT 1D beta; 5 HT1B; 5 HT1DB; 5 hydroxytryptamine (serotonin) receptor 1B; 5 hydroxytryptamine 1B receptor; HTR1B… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18952090 | Uphouse L, Hiegel C, Guptarak J, Maswood N: reduces the effect of the 1B/1D receptor antagonist, GR 127935, on lordosis behavior. Horm Behav. 2009 Jan;55(1):169-74. Epub 2008 Oct 8. Rats received a bilateral infusion with 200 ng of the 5-HT (1B/1D) receptor antagonist, N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)-1-1'-biphenyl-4-carboxamide hydrochloride (GR 127935), into the ventromedial nucleus of the hypothalamus (VMN), followed by a 5 min restraint or home cage experience. |
32(0,1,1,2) | Details |
| 19356724 | Lozano-Cuenca J, Munoz-Islas E, Gonzalez-Hernandez A, Centurion D, Cobos-Puc LE, Sanchez-Lopez A, Pertz HH, Villalon CM: Pharmacological profile of the inhibition by dihydroergotamine and methysergide on the cardioaccelerator sympathetic outflow in pithed rats. Eur J Pharmacol. 2009 Jun 10;612(1-3):80-6. Epub 2009 Apr 6. Using physiological saline or antagonists (given as i.v. bolus injections), the cardiac sympatho-inhibition induced by either DHE (3.1 microg/kg x min) or methysergide (300 microg/kg x min) was: (1) unaffected by saline (1 ml/kg); (2) partially blocked by the antagonists rauwolscine (300 microg/kg; alpha (2)) or N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl) [1,1,-biphenyl]-4-carboxamide hydrochloride monohydrate (GR127935, 300 microg/kg; 5-HT (1B/1D)); and (3) completely antagonised by the combination rauwolscine plus GR127935. |
32(0,1,1,2) | Details |
| 19211971 | Przegalinski E, Golda A, Filip M: Effects of (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats. Pharmacol Rep. 2008 Nov-Dec;60(6):798-810. Numerous data indicated a significance for the brain dopaminergic pathways in the behavioral effects of cocaine, however recent research also demonstrated involvement of neurotransmission and particularly 5-HT (1B) receptors in the reinforcing, discriminative stimulus and sensitizing effects of cocaine. |
7(0,0,0,7) | Details |
| 19460365 | Munoz-Islas E, Lozano-Cuenca J, Gonzalez-Hernandez A, Ramirez-Rosas MB, Sanchez-Lopez A, Centurion D, Maassenvandenbrink A, Villalon CM: Spinal inhibits -induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Eur J Pharmacol. 2009 Aug 1;615(1-3):133-8. Epub 2009 May 19. |
4(0,0,0,4) | Details |
| 17880377 | Garcia M, Moran A, Martin ML, Ortizde Urbina AV, San Roman L: Diabetes-induced changes in modulation of vagally-induced bradycardia in rat heart. Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1199-206. Attenuation of the vagally induced bradycardia evoked by the higher doses of 5-CT was reproduced by L-694,247 (50 microg/kg), a selective agonist for the non-rodent 5-HT (1B) and 5-HT (1D) receptors. |
2(0,0,0,2) | Details |
| 18248912 | Shen KZ, Johnson SW: inhibits synaptic transmission in rat subthalamic nucleus neurons in vitro. Neuroscience. 2008 Feb 19;151(4):1029-33. Epub 2007 Dec 8. The 5-HT1B receptor antagonist NAS-181 significantly antagonized -induced inhibitions of EPSCs and IPSCs. |
2(0,0,0,2) | Details |
| 19741007 | Chen L, Salinas GD, Li X: Regulation of serotonin 1B receptor by glycogen synthase kinase-3. . Mol Pharmacol. 2009 Dec;76(6):1150-61. Epub 2009 Sep 9. |
1(0,0,0,1) | Details |