| Name | carbonic anhydrase |
|---|---|
| Synonyms | CA IX; CA1; Carbonic anhydrase I; CA2; CAII; Carbonic anhydrase II; Carbonic dehydratase; Carbonic anhydrase III… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19375921 | Winum JY, Innocenti A, Scozzafava A, Montero JL, Supuran CT: Carbonic anhydrase inhibitors. Bioorg Med Chem. 2009 May 15;17(10):3649-52. Epub 2009 Apr 5. The best hCA I and II inhibitor was biphenyl boronic acid with, a K (I) of 3.7-4.5 microM, whereas the remaining derivatives showed inhibition constants in the range of 6.0-1560 microM for hCA I and of 6.0-1050 microM for hCA II, respectively. hCA IX and XII were effectively inhibited by most of the aromatic boronic acids (K (I) s of 7.6-12.3 microM) whereas the arylalkenyl and aryl-alkyl derivatives generally showed weaker inhibitory properties (K (I) s of 34-531 microM). |
83(1,1,1,3) | Details |
| 18608752 | Morsy SM, Badawi AM, Cecchi A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem. 2009 Apr;24(2):499-505. Reaction of 4,4-biphenyl-disulfonyl with aromatic/heterocyclic sulfonamides also incorporating a free amino group, such as 4-aminobenzenesulfonamide, 4-aminoethyl-benzenesulfonamide, 6-chloro-4--1,3-disulfonamide or 5-amino-1,3,4-thiadiazole-2-sulfonamide afforded bis-sulfonamides which have been tested as inhibitors of the zinc enzyme carbonic anhydrase (CA, EC 4..2.1.1). |
33(0,1,1,3) | Details |
| 19427356 | Sun LN, Shen J, Su F, Wang Q, Zhu YJ, Lou XE, Liang HW, Bruce IC, Xia Q: Bicyclol attenuates oxidative stress and neuronal damage following transient forebrain ischemia in mouse cortex and hippocampus. Neurosci Lett. 2009 Aug 7;459(2):84-7. Epub 2009 May 7. We found that extensive neuronal death occurred in the cortex and the CA1 area of the hippocampus at day 7 after IR and that bicyclol significantly attenuated IR-induced neuronal death in a dose-dependent manner. |
1(0,0,0,1) | Details |
| 20148564 | Woo LW, Jackson T, Putey A, Cozier G, Leonard P, Acharya KR, Chander SK, Purohit A, Reed MJ, Potter BV: Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. J Med Chem. 2010 Mar 11;53(5):2155-70. At 1 mg/kg po, 20 and 23 reduced plasma levels strongly and inhibited liver STS activity potently in vivo. 23 is nonestrogenic and potently inhibits carbonic anhydrase II (IC (50) 86 nM). |
1(0,0,0,1) | Details |