Protein Information

Name catalase
Synonyms CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases…

Compound Information

Name biphenyl
CAS 1,1′-biphenyl

Reference List

PubMed Abstract RScore(About this table)
18691649 Venkatesha VA, Venkataraman S, Sarsour EH, Kalen AL, Buettner GR, Robertson LW, Lehmler HJ, Goswami PC: Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells. Free Radic Biol Med. 2008 Oct 15;45(8):1094-102. Epub 2008 Jul 22.
8(0,0,1,3) Details
18640730 Gunawickrama SH, Aarsaether N, Orbea A, Cajaraville MP, Goksoyr A: PCB77 (3,3',4,4'-tetrachlorobiphenyl) co-exposure prolongs CYP1A induction, and sustains oxidative stress in B (a) P-exposed turbot, Scophthalmus maximus, in a long-term study. Aquat Toxicol. 2008 Aug 29;89(2):65-74. Epub 2008 Jun 8.

The results indicate synergistic effects of polycyclic aromatic hydrocarbon (PAH) and polychlorinated biphenyl (PCB) exposure in the aquatic environment.
Both exposed groups demonstrated evidence for lasting oxidative stress as hepatic superoxide dismutase, catalase and glutathione peroxidase activities were significantly altered (p <0.05) with symptomatic pro-oxidant associations among them.
1(0,0,0,1) Details
19429327 Shen X, Tang Y, Yang R, Yu L, Fang T, Duan JA: The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. J Ethnopharmacol. 2009 Apr 21;122(3):555-60. Epub 2009 Feb 7.


Product of lipid peroxidation (MDA), activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced glutathione (GSH) contents were evaluated for oxidative stress in hepatic injury.
1(0,0,0,1) Details
19394609 Cigremis Y, Kart A, Karaman M, Erdag D: Attenuation of ischemia-reperfusion injury with Marrubium cordatum treatment in ovarian torsion-detorsion model in rabbits. Fertil Steril. 2010 Mar 15;93(5):1455-63. Epub 2009 Apr 25.


Glutathione, malondialdehyde, catalase, and glutathione peroxidase were measured.
3(0,0,0,3) Details
20307652 Chaudhuri L, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC: Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle. Free Radic Biol Med. 2010 Mar 19.

Pretreatment of quiescent cells with polyethylene glycol-conjugated superoxide dismutase and catalase suppressed 4-Cl-BQ induced increase in ROS levels, which was consistent with an increase in cyclin D1 accumulation, and entry into S phase.
1(0,0,0,1) Details
19796678 Zhu Y, Kalen AL, Li L, Lehmler HJ, Robertson LW, Goswami PC, Spitz DR, Aykin-Burns N: Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure. Free Radic Biol Med. 2009 Dec 15;47(12):1762-71. Epub 2009 Sep 28.

Finally, treatment with either N-acetylcysteine (NAC) or the combination of polyethylene glycol (PEG)-conjugated CuZnSOD and PEG-catalase added 1 h after PCBs significantly protected these cells from PCB toxicity.
2(0,0,0,2) Details
17991446 Marengo B, De Ciucis C, Verzola D, Pistoia V, Raffaghello L, Patriarca S, Balbis E, Traverso N, Cottalasso D, Pronzato MA, Marinari UM, Domenicotti C: Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma. Free Radic Biol Med. 2008 Feb 1;44(3):474-82. Epub 2007 Oct 22.


BSO susceptibility of SK-N-BE-2C, a representative example of MYCN-amplified cells, has been attributed to stimulation of total SOD activity in the absence of changes in the level and the activity of catalase.
1(0,0,0,1) Details
18274624 Robertson LW, Berberian I, Borges T, Chen LC, Chow CK, Glauert HP, Filser JG, Thomas H: Suppression of Peroxisomal Enzyme Activities and Cytochrome P450 4A Isozyme Expression by Congeneric Polybrominated and Polychlorinated Biphenyls. PPAR Res. 2007;2007:15481.

One week later, the activities of catalase, peroxisomal fatty acyl-CoA oxidase, and peroxisomal beta-oxidation as well as cytochrome P450 4A (CYP4A) protein content were determined in subcellular liver fractions.
None of the peroxisomal enzyme activities were significantly increased by any of the halogenated biphenyl congeners tested.
1(0,0,0,1) Details
18502095 Murugesan P, Muthusamy T, Balasubramanian K, Arunakaran J: Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells. Reprod Toxicol. 2008 Aug;25(4):447-54. Epub 2008 Apr 18.

In addition, Leydig cellular enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), gamma-glutamyl transpeptidase (gamma-GT), glutathione-S-transferase (GST) and non-enzymatic antioxidants such as vitamin C and E were assayed.
1(0,0,0,1) Details
17967502 Saito J, Shibuya K, Nagase H: Anti-clastogenic effect of magnolol on benzo (a) pyrene-induced clastogenicity in mice. Food Chem Toxicol. 2008 Feb;46(2):694-700. Epub 2007 Sep 26.


In order to elucidate the mechanism behind this effect, we measured the activity of the detoxifying enzymes [UDP-glucuronosyltransferase (UGT) and glutathione-S-transferase (GST)] and antioxidative enzymes [superoxide dismutase (SOD) and catalase] in the liver when treated with an oral administration of magnolol at various administration times.
1(0,0,0,1) Details
18361750 Spada PD, de Souza GG, Bortolini GV, Henriques JA, Salvador M: Antioxidant, mutagenic, and antimutagenic activity of frozen fruits. J Med Food. 2008 Mar;11(1):144-51.


Antioxidant assays included 2,2-diphenyl-1-picrylhydrazyl radical (DPPH (.)) scavenging activity and determination of superoxide dismutase (SOD)- and catalase (CAT)-like activities.
1(0,0,0,1) Details
18022343 Lee SJ, Lim KT: Glycoprotein of Zanthoxylum piperitum DC has a hepatoprotective effect via anti-oxidative character in vivo and in vitro. Toxicol In Vitro. 2008 Mar;22(2):376-85. Epub 2007 Oct 14.


In addition, administration of ZPDC glycoprotein (20mg/kg) lowers the levels of lactate dehydrogenase, alanine transaminase, and thiobarbituric acid reactive substances, whereas increases that of nitric oxide, accompanying the normalizing effects on the activity of hepatic anti-oxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) in mouse model of carbon tetrachloride-stimulated acute liver injury.
1(0,0,0,1) Details
18371952 Zhao J, Chen H, Li Y: Protective effect of bicyclol on acute alcohol-induced liver injury in mice. Eur J Pharmacol. 2008 May 31;586(1-3):322-31. Epub 2008 Feb 29.


In addition, bicyclol remarkably alleviated the formation of thiobarbituric acid-reactive substance and restored impaired antioxidants, including glutathione, superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase.
1(0,0,0,1) Details
18601970 Vardi N, Parlakpinar H, Ozturk F, Ates B, Gul M, Cetin A, Erdogan A, Otlu A: Potent protective effect of apricot and beta-carotene on methotrexate-induced intestinal oxidative damage in rats. Food Chem Toxicol. 2008 Sep;46(9):3015-22. Epub 2008 Jun 14.


Parallel to histological results, malondialdehyde (MDA) content and myeloperoxidase (MPO) activity were found to be increased, whereas superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GP-x) activities and glutathione (GSH) content were decreased in the MTX group.
1(0,0,0,1) Details
19093866 Yang Z, Zheng Y, Cao S: Effect of high oxygen atmosphere storage on quality, antioxidant enzymes, and DPPH-radical scavenging activity of Chinese bayberry fruit. J Agric Food Chem. 2009 Jan 14;57(1):176-81.


High O (2) treatment was less stressful as reflected by having the significantly lower malonaldehyde contents and higher catalase, ascorbic acid peroxidase, and peroxidase activities during storage.
1(0,0,0,1) Details
17910617 Manna P, Sinha M, Sil PC: Protection of arsenic-induced hepatic disorder by arjunolic acid. Basic Clin Pharmacol Toxicol. 2007 Nov;101(5):333-8.


Administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly reduced the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione S-transferase, glutathione reductase and glutathione peroxidase as well as depleted the level of reduced glutathione and total thiols.
1(0,0,0,1) Details
18538307 Duong TT, Antao S, Ellis NA, Myers SJ, Witting PK: Supplementation with a synthetic polyphenol limits oxidative stress and enhances neuronal cell viability in response to hypoxia-re-oxygenation injury. Brain Res. 2008 Jul 11;1219:8-18. Epub 2008 Apr 27.

Expression of genes encoding for hypoxia-inducible factor 1-alpha (HIF1-alpha), inducible haemoxygenase-1 (HO-1), glucose transporter-1 (Glut-1), the oxygen-sensor neuroglobin (Nb) and Cu,Zn-superoxide dismutase (SOD1), catalase (CAT) and glutathione peroxidase-1 (Gpx-1) increased significantly in response to the insult.
In contrast, ROS accumulation, the endogenous gene response and cell death was limited in neuronal cells pre-incubated with 50 or 100, but not 10 microM of the phenolic antioxidant 3,3',5,5'-tetra-t-butyl-biphenyl-4,4'-diol (BP) prior to H/R injury.
1(0,0,0,1) Details
17965160 Patrauchan MA, Florizone C, Eapen S, Gomez-Gil L, Sethuraman B, Fukuda M, Davies J, Mohn WW, Eltis LD: Roles of ring-hydroxylating dioxygenases in styrene and benzene catabolism in Rhodococcus jostii RHA1. J Bacteriol. 2008 Jan;190(1):37-47. Epub 2007 Oct 26.

Finally, catalases were more abundant during growth on nonpolar aromatic compounds than on aromatic acids.
Proteomics and targeted gene disruption were used to investigate the catabolism of benzene, styrene, biphenyl, and ethylbenzene in Rhodococcus jostii RHA1, a well-studied soil bacterium whose potent polychlorinated biphenyl (PCB)-transforming properties are partly due to the presence of the related Bph and Etb pathways.
1(0,0,0,1) Details
19445841 Ozdemir S, Tandogan B, Ulusu NN, Turan B: Angiotensin II receptor blockage prevents diabetes-induced oxidative damage in rat heart. Folia Biol. 2009;55(1):11-6.


In this study we aimed to investigate the effect of angiotensin II type 1 (AT1) receptor blockage on some antioxidant enzymes such as glucose- 6-phosphate dehydrogenase (G6PD), 6-phoshogluconate dehydrogenase (6PGD), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px), and catalase (CAT) in the heart of streptozotocin (STZ)-induced diabetic rats.
1(0,0,0,1) Details
20074268 Atessahin A, Turk G, Yilmaz S, Sonmez M, Sakin F, Ceribasi AO: Modulatory Effects of Lycopene and Ellagic Acid on Reproductive Dysfunction Induced by Polychlorinated Biphenyl (Aroclor 1254) in Male Rats. Basic Clin Pharmacol Toxicol. 2010 Jan 14.

LP and EA treatments to AR-treated rats markedly decreased abnormal sperm rates, testicular thiobarbituric acid reactive substances level, and increased the glutathione (GSH) level, GSH-peroxidase, catalase activities and epidiymal sperm concentration as compared with the alone AR group.
1(0,0,0,1) Details
19445998 Kong CS, Kim JA, Qian ZJ, Kim YA, Lee JI, Kim SK, Nam TJ, Seo Y: Protective effect of isorhamnetin 3-O-beta-D-glucopyranoside from Salicornia herbacea against oxidation-induced cell damage. Food Chem Toxicol. 2009 Aug;47(8):1914-20. Epub 2009 May 13.


Further, antioxidative mechanisms by compound 1 were examined by measuring the intracellular glutathione (GSH) level and expression levels of antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione reductase and heme oxygenase-1 (HO-1).
1(0,0,0,1) Details
18273903 Sinha M, Manna P, Sil PC: Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain. J Biochem Mol Toxicol. 2008 Feb;22(1):15-26.


Oral administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly decreased the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase, the level of cellular metabolites, reduced glutathione, total thiols and increased the level of oxidized glutathione.
1(0,0,0,1) Details
19210495 Yu YN, Chen H, Li Y: Effect of bicyclol on cisplatin-induced hepatotoxicity in the hepatocarcinoma 22 tumour-bearing mice. Basic Clin Pharmacol Toxicol. 2009 Apr;104(4):300-5. Epub 2009 Feb 2.


The formation of liver malondialdehyde with a concomitant reduction of reduced glutathione was also inhibited by bicyclol, while the activities of liver superoxide dismutase, catalase and glutathione peroxidase were all increased, respectively.
1(0,0,0,1) Details
18956176 Yu YN, Chen H, Li Y: Protect effect of bicyclol on cisplatin-induced nephrotoxicity in mice. Arch Toxicol. 2009 Apr;83(4):381-7. Epub 2008 Oct 28.


The formation of kidney malondialdehyde with a concomitant reduction of reduced glutathione were also inhibited by bicyclol, while the activities of kidney superoxide dismutase, catalase and glutathione peroxidase were all increased, respectively.
1(0,0,0,1) Details