Protein Information

Name protein kinase B
Synonyms AKT; PKB; Protein kinase B; AKT 1; AKT1; C AKT; Oncogene AKT1; PKB alpha…

Compound Information

Name biphenyl
CAS 1,1′-biphenyl

Reference List

PubMed Abstract RScore(About this table)
18574825 Mills SJ, Vandeput F, Trusselle MN, Safrany ST, Erneux C, Potter BV: Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the PH domain of protein kinase Balpha. Chembiochem. 2008 Jul 21;9(11):1757-66.

The most potent ligand for the PKBalpha PH domain, measured by inhibition of biotinylated diC (8)-PtdIns (3,4) P (2) binding, is biphenyl 2,3',4,5',6-pentakisphosphate (4, K (i)=27 nm).
33(0,1,1,3) Details
18367166 Chang HL, Chang FR, Chen JS, Wang HP, Wu YH, Wang CC, Wu YC, Hwang TL: Inhibitory effects of 16-hydroxycleroda-3,13 (14) E-dien-15-oic acid on superoxide anion and elastase release in human neutrophils through multiple mechanisms. Eur J Pharmacol. 2008 May 31;586(1-3):332-9. Epub 2008 Mar 4.


Furthermore, PL3S attenuated the FMLP-induced protein kinase B (AKT) and p38 mitogen-activated protein kinase phosphorylation.
1(0,0,0,1) Details
19182370 Zhang R, Kang KA, Piao MJ, Ko DO, Wang ZH, Chang WY, You HJ, Lee IK, Kim BJ, Kang SS, Hyun JW: Preventive effect of 7,8-dihydroxyflavone against oxidative stress induced genotoxicity. Biol Pharm Bull. 2009 Feb;32(2):166-71.


Furthermore, 7,8-dihydroxyflavone activated the protein kinase B (PKB, Akt) signal pathway, which is a major survival signal pathway.
1(0,0,0,1) Details