| Name | ERK1 |
|---|---|
| Synonyms | ERK 1; ERK1; ERT 2; ERT2; Extracellular signal regulated kinase 1; Extracellular signal related kinase 1b; Extracellular signal related kinase 1c; HS44KDAP… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19619627 | Ptak A, Gut P, Blachuta M, Rak A, Gregoraszczuk EL: Direct inhibition of ERK1/2 phosphorylation as a possible mechanism for the antiproliferative action of 3,4-diOH-PCB3 in the MCF-7 cell line. Toxicol Lett. 2009 Oct 28;190(2):187-92. Epub 2009 Jul 18. |
4(0,0,0,4) | Details |
| 18783396 | Jing L, Li WM, Zhou LJ, Li S, Kou JJ, Song J: Expression of renin-angiotensin system and peroxisome proliferator-activated receptors in alcoholic cardiomyopathy. Alcohol Clin Exp Res. 2008 Nov;32(11):1999-2007. Epub 2008 Sep 9. Finally, extracellular signal regulated kinase 1 and 2 (ERK1/2) was shown to play a key role in the regulation of protein expression of PPARalpha and PPARgamma. |
2(0,0,0,2) | Details |
| 19808375 | Kassiri Z, Zhong J, Guo D, Basu R, Wang X, Liu PP, Scholey JW, Penninger JM, Oudit GY: Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail. 2009 Sep;2(5):446-55. Epub 2009 Jun 15. Loss of ACE2 also leads to increased neutrophilic infiltration in the infarct and peri-infarct regions, resulting in upregulation of inflammatory cytokines, interferon-gamma, interleukin-6, and the chemokine, monocyte chemoattractant protein-1, as well as increased phosphorylation of ERK1/2 and JNK1/2 signaling pathways. |
1(0,0,0,1) | Details |
| 18416822 | Richardson D, Pearson RG, Kurian N, Latif ML, Garle MJ, Barrett DA, Kendall DA, Scammell BE, Reeve AJ, Chapman V: Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther. 2008;10(2):R43. Epub 2008 Apr 16. Cannabinoid receptor stimulation of fibroblast-like cells from OA and RA patients produced a time-dependent phosphorylation of extracellular signal-regulated kinase (ERK)-1 and ERK-2 which was significantly blocked by the CB1 antagonist SR141716A. FAAH was active in the synovia of OA and RA patients and was sensitive to inhibition by URB597 (3'-(aminocarbonyl) [1,1'-biphenyl]-3-yl)-cyclohexylcarbamate). |
1(0,0,0,1) | Details |
| 18641058 | Jin YC, Kim KJ, Kim YM, Ha YM, Kim HJ, Yun UJ, Bae KH, Kim YS, Kang SS, Seo HG, Lee JH, Chang KC: Anti-apoptotic effect of magnolol in myocardial ischemia and reperfusion injury requires extracellular signal-regulated kinase1/2 pathways in rat in vivo. Exp Biol Med. 2008 Oct;233(10):1280-8. Epub 2008 Jul 18. Taken together, we concluded that magnolol inhibits apoptosis through enhancing the activation of ERK1/2 and modulation of the Bcl-xl proteins which brings about reduction of infarct size and improvement of cardiac function in I/R-induced injury. |
1(0,0,0,1) | Details |
| 18207396 | Peifer C, Urich R, Schattel V, Abadleh M, Rottig M, Kohlbacher O, Laufer S: Implications for selectivity of 3,4-diarylquinolinones as p38alphaMAP kinase inhibitors. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1431-5. Epub 2008 Jan 5. In this study we report on the specificity profiling of the MAP kinase inhibitors 1, 2, and 3 in a panel of 78 protein kinases including the MAPK isoforms p38 (alpha,beta,gamma,delta), JNK1/2/3, and ERK1/2/8 showing 3-(4-fluorophenyl)-4-pyridin-4-ylquinolin-2 (1H)-one (1) to be highly selective for p38alphaMAPK with an IC (50) of 1.8 microM. |
1(0,0,0,1) | Details |
| 18413146 | Idris A, Mrak E, Greig I, Guidobono F, Ralston SH, van 't Hof R: ABD56 causes osteoclast apoptosis by inhibiting the NFkappaB and ERK pathways. Biochem Biophys Res Commun. 2008 Jun 20;371(1):94-8. Epub 2008 Apr 14. ABD56 completely abolished RANKL-induced IkappaB and ERK1/2 phosphorylation. |
1(0,0,0,1) | Details |