Protein Information

Name fibronectin
Synonyms CIG; MSF; Cold insoluble globulin; FINC; FN; FN1; Fibronectin; Fibronectin 1…

Compound Information

Name biphenyl
CAS 1,1′-biphenyl

Reference List

PubMed Abstract RScore(About this table)
19906432 Bergamo A, Masi A, Peacock AF, Habtemariam A, Sadler PJ, Sava G: In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model. J Inorg Biochem. 2010 Jan;104(1):79-86. Epub 2009 Oct 14.

We have compared the organometallic arene complexes [(eta (6)-biphenyl) M (ethylenediamine) Cl](+) RM175 (M=Ru (II)) and its isostructural osmium (II) analogue AFAP51 (M=Os (II)) for their ability to induce cell detachment resistance from fibronectin, collagen IV and poly-l-lysine, and cell re-adhesion after treatment, their effects on cell migration and cell viability, on matrix metalloproteinases production, and on primary tumour growth of MCa mammary carcinoma, the effect of human serum albumin on their cytotoxicity.
31(0,1,1,1) Details
19759519 Iwasawa M, Miyazaki T, Nagase Y, Akiyama T, Kadono Y, Nakamura M, Oshima Y, Yasui T, Matsumoto T, Nakamura T, Kato S, Hennighausen L, Nakamura K, Tanaka S: The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice. J Clin Invest. 2009 Oct;119(10):3149-59. doi: 10.1172/JCI39819. Epub 2009 Sep 14.


In addition, Bcl-x cKO osteoclasts displayed increased c-Src activity, which was linked to increased levels of vitronectin and fibronectin expression.
2(0,0,0,2) Details
20183293 Sun H, Liu GT: Inhibitory effect of anti-hepatitis drug bicyclol on invasion of human hepatocellular carcinoma MHCC97-H cells with high metastasis potential and its relative mechanisms. J Asian Nat Prod Res. 2009 Jun;11(6):576-83.


MTT assay was performed to evaluate the cytotoxicity of 1 to MHCC97-H cells and its inhibitory effect on the adhesion of these cells to laminin (LN) and fibronectin (FN).
1(0,0,0,1) Details
19553350 Noh H, Oh EY, Seo JY, Yu MR, Kim YO, Ha H, Lee HB: Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. Am J Physiol Renal Physiol. 2009 Sep;297(3):F729-39. Epub 2009 Jun 24.


Levels of mRNA expression of fibronectin and alpha-smooth muscle actin were decreased, whereas E-cadherin mRNA was increased when HDAC-2 was knocked down using RNA interference in NRK52-E cells.
1(0,0,0,1) Details