| 20337461 |
Hamada M, Nakamura M, Kiuchi M, Marukawa K, Tomatsu A, Shimano K, Sato N, Sugahara K, Asayama M, Takagi K, Adachi K: Removal of Sphingosine 1-Phosphate Receptor-3 (S1P (3)) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P (1) Agonists with Reduced Effect on Heart Rate. J Med Chem. 2010 Mar 25.
Only 2-amino-2-[2-[2'-fluoro-4'-(4-methylphenylthio) biphenyl-4-yl] ethyl] propane -1,3-diol (6d) was identified as a desired S1P (1) receptor agonist having both the immunomodulatory activity and an attenuated effect on heart rate by a unique screening flow using in vivo evaluating systems primarily. |
34(0,1,1,4) |
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