| 18257748 |
Cruz-Dominguez MP, Villalobos-Molina R, Miliar-Garcia A, Montes-Cortes DH, Resendiz-Ramirez AC, Asbun-Bojalil J, Cervantes-Cruz J, Castillo-Hernandez MC, Castillo-Henkel C: Evidence of alpha1-adrenoceptor functional changes in omental arteries of patients with end-stage renal disease. Auton Autacoid Pharmacol. 2008 Jan;28(1):19-27.
1 Alpha1-Adrenoceptor (alpha1-AR) subtypes were characterized in isolated omental arteries obtained after abdominal surgery in patients with end-stage renal disease (ESRD) or with Diabetes Mellitus type 2 plus ESRD (ESRD-DM). 2 Omental arteries from patients with ESRD and ESRD-DM elicited a significant increase in sensitivity to phenylephrine with a pD (2) (-log EC50) of 6.7 and 6.6, respectively, vs. the control (5.8, P < 0.001). 3 Stimulation with phenylephrine was conducted in the presence or absence of selective alpha1-AR competitive antagonists: 5-methylurapidil (alpha1A-), AH11110A (1-[biphenyl-2-yloxy]-4-imino-4-piperidin-1-yl-butan-2-ol; alpha1B-) and BMY7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-8-azaspiro [4.5] decane-7,9-dione; alpha (1D)-). |
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