| Name | NADPH cytochrome P450 reductase |
|---|---|
| Synonyms | CPR; CYPOR; Cytochrome P 450 reductase; Cytochrome P450 reductase; NADPH cytochrome P450 reductase; NADPH cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450R… |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9733020 | Simon Giavarotti KA, Rodrigues L, Rodrigues T, Junqueira VB, Videla LA: Liver microsomal parameters related to oxidative stress and antioxidant systems in hyperthyroid rats subjected to acute lindane treatment. Free Radic Res. 1998 Jul;29(1):35-42. The administration of lindane to hyperthyroid animals led to a further increase in the molecular activity of NADPH-cytochrome P450 reductase and in the O2.- production/SOD activity ratio, and decrease of hepatic content, in a magnitude exceeding the sum of effects elicited by the separate treatments, as previously reported for depletion. |
32(0,1,1,2) | Details |
| 14631868 | Fernandez V, Massa L, Quinones L, Simon-Giavarotti KA, Giavarotti L, D'Almeida V, Azzalis LA, Junqueira VB, Videla LA: Effects of gamma-hexachlorocyclohexane and L-3,3',5- on rat liver cytochrome P4502E1-dependent activity and content in relation to microsomal generation. Biol Res. 2003;36(3-4):359-65. Concomitantly, the molecular activity of NADPH-cytochrome p450 reductase was enhanced by 90 and 69% by HCCH and T3, respectively. |
2(0,0,0,2) | Details |
| 10817630 | Videla LA, Arisi AC, Fuzaro AP, Koch OR, Junqueira VB: Prolonged phenobarbital pretreatment abolishes the early oxidative stress component induced in the liver by acute lindane intoxication. Toxicol Lett. 2000 Apr 10;115(1):45-51. These changes were observed in the absence of changes in either microsomal functions (cytochrome P450 content, -dependent production, and NADPH-cytochrome P450 reductase or oxidase activities) or in oxidative stress-related enzymatic activities (superoxide dismutase, catalase, peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, and glutathione-S-transferases), over control values. |
1(0,0,0,1) | Details |
| 1723229 | Junqueira VB, Simizu K, Pimentel R, Azzalis LA, Barros SB, Koch O, Videla LA: Effect of phenobarbital and 3-methylcholanthrene on the early oxidative stress component induced by lindane in rat liver. Xenobiotica. 1991 Aug;21(8):1053-65. PB pretreatment produced a 50% increase in lipid peroxidation (TBAR) by liver homogenates and microsomes, an effect accompanied by increases in cytochrome P-450, -cytochrome P-450 reductase, oxidase and microsomal production, MC pretreatment resulted in increases in liver cytochrome P-450 and oxidase only. 3. |
1(0,0,0,1) | Details |