Protein Information

Name DTNB
Synonyms Beta dystrobrevin; DTN B; DTNB; Dystrobrevin beta; Dystrobrevin betas

Compound Information

Name chlorothalonil
CAS 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile

Reference List

PubMed Abstract RScore(About this table)
1149170 Long JW, Siegel MR: Mechanism of action and fate of the fungicide chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) in biological systems. 2. Chem Biol Interact. 1975 Jun;10(6):383-94.

Because 5,5' dithiobis-(2-nitrobenzoic) acid (DTNB) reduced the binding of 14C-labeled fungicide by approximately 90% it is postulated that chlorothalonil affects catalytic activity by reacting with the 4 sulfhydryl sites (cysteine-149) responsible for the binding of GAP.
31(0,1,1,1) Details