Protein Information

Name thyroxine binding globulin
Synonyms SERPINA 7; SERPINA7; Serpin A7; T4 binding globulin; TBG; Thyroxine binding globulin; Thyroxine binding globulin of serum; Thyroxine binding globulin precursor…

Compound Information

Name pentachlorophenol
CAS 2,3,4,5,6-pentachlorophenol

Reference List

PubMed Abstract RScore(About this table)
19590699 Dallaire R, Muckle G, Dewailly E, Jacobson SW, Jacobson JL, Sandanger TM, Sandau CD, Ayotte P: Thyroid hormone levels of pregnant inuit women and their infants exposed to environmental contaminants. Environ Health Perspect. 2009 Jun;117(6):1014-20. Epub 2009 Jan 29.

METHODS: We measured thyroid hormone parameters [thyroid stimulating hormone (TSH), free thyroxine (fT (4)), total triiodothyronine (T (3)), thyroxine-binding globulin (TBG)] and concentrations of several contaminants [PCB-153, hydroxylated metabolites of PCBs (HO-PCBs), pentachlorophenol (PCP) and hexachlorobenzene (HCB)] in maternal plasma at delivery (n = 120), in umbilical cord plasma (n = 95), and in infant plasma at 7 months postpartum (n = 130).
81(1,1,1,1) Details
8478982 Heussen GA, Schefferlie GJ, Talsma MJ, van Til H, Dohmen MJ, Brouwer A, Alink GM: Effects on thyroid hormone metabolism and depletion of lung vitamin A in rats by airborne particulate matter. J Toxicol Environ Health. 1993 Apr;38(4):419-34.

Pentachlorophenol, a compound with known inhibitory activity on T4-TTR binding, was detected in the organic acid fraction of both a cigarette smoke sample and an outdoor APM sample.
A third aim was to compare the interaction of APM extracts with TTR and thyroxine-binding globulin (TBG), the major carrier protein for thyroxine in humans.
1(0,0,0,1) Details