| Name | thyroid hormone receptor (protein family or complex) |
|---|---|
| Synonyms | Thyroid hormone receptor; Thyroid hormone receptors |
| Name | pentachlorophenol |
|---|---|
| CAS | 2,3,4,5,6-pentachlorophenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19082768 | Kawaguchi M, Morohoshi K, Saita E, Yanagisawa R, Watanabe G, Takano H, Morita M, Imai H, Taya K, Himi T: Developmental exposure to pentachlorophenol affects the expression of thyroid hormone receptor beta1 and synapsin I in brain, resulting in thyroid function vulnerability in rats. Endocrine. 2008 Jun;33(3):277-84. |
32(0,1,1,2) | Details |
| 12553426 | Yamauchi K, Eguchi R, Shimada N, Ishihara A: The effects of endocrine-disrupting chemicals on thyroid hormone binding to Xenopus laevis transthyretin and thyroid hormone receptor. Clin Chem Lab Med. 2002 Dec;40(12):1250-6. The xTTR's relative affinities for diethylstilbestrol, pentachlorophenol and ioxynil were 10 (-1)- to 10 (-2)-fold less than that for T3. |
2(0,0,0,2) | Details |
| 12581883 | Ishihara A, Sawatsubashi S, Yamauchi K: Endocrine disrupting chemicals: interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors. Mol Cell Endocrinol. 2003 Jan 31;199(1-2):105-17. Scatchard analysis revealed DES, pentachlorophenol and ioxynil as competitive inhibitors of [125I] T (3) binding to cTTR and bTTR. |
2(0,0,0,2) | Details |
| 13129501 | Ishihara A, Nishiyama N, Sugiyama S, Yamauchi K: The effect of endocrine disrupting chemicals on thyroid hormone binding to Japanese quail transthyretin and thyroid hormone receptor. Gen Comp Endocrinol. 2003 Oct 15;134(1):36-43. Diethylstilbestrol, ioxynil (IC50 =1.1+/-0.5 nM) and pentachlorophenol (IC50 = 6.3+/-3.8 nM) displaced [125I] T3 from qTTR more effectively than unlabeled T3 (IC50 = 9.7+/-0.9 nM) did. |
2(0,0,0,2) | Details |
| 17532181 | Jugan ML, Levy-Bimbot M, Pomerance M, Tamisier-Karolak S, Blondeau JP, Levi Y: A new bioluminescent cellular assay to measure the transcriptional effects of chemicals that modulate the alpha-1 thyroid hormone receptor. Toxicol In Vitro. 2007 Sep;21(6):1197-205. Epub 2007 Apr 14. Several halogenated phenolic (3,3',5,5'-tetrabromobisphenol A, 3,3',5,5'-tetrachlorobisphenol A, 4--2',3,4',5,6'-pentachlorobiphenyl) and (pentachlorophenol, 2,4,6-triiodophenol) compounds suspected of being thyroid-disrupting environmental chemicals induced partial agonistic and/or complex competitive/uncompetitive antagonistic responses in PC-DR-LUC cells at micromolar concentrations. |
1(0,0,0,1) | Details |