| Name | transferase |
|---|---|
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| Name | pentachlorophenol |
|---|---|
| CAS | 2,3,4,5,6-pentachlorophenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2027344 | Jansson K, Jansson V: Induction of mutation in V79 Chinese hamster cells by tetrachlorohydroquinone, a metabolite of pentachlorophenol. Mutat Res. 1991 May;260(1):83-7. Tetrachlorohydroquinone (TCHQ) and tetrachlorocatechol (TCC), two metabolites of the environmental mutagen and carcinogen pentachlorophenol, were tested without exogenous activation in V79 Chinese hamster cells for the induction of mutation at the phosphoribosyl transferase (HPRT) locus to 6-thioguanine resistance (TGr) and at the Na/K-ATPase locus to ouabain resistance (OuaR). |
81(1,1,1,1) | Details |
| 60234 | Dall-Larsen T, Kryvi H, Klungsoyr L: Dinitrophenol, dicoumarol and pentachlorophenol as inhibitors and parasite substrates in the ATP phosphoribosyltransferase reaction. Eur J Biochem. 1976 Jul 15;66(3):443-6. Dicoumarol and pentachlorophenol partly prevent the binding of ATP and AMP to the transferase. |
81(1,1,1,1) | Details |
| 3748065 | Jansson K, Jansson V: Inability of chlorophenols to induce 6-thioguanine-resistant mutants in V79 Chinese hamster cells. Mutat Res. 1986 Aug-Sep;171(2-3):165-8. The induction of mutation at the - phosphoribosyl transferase locus and cytotoxicities of 6 different chlorophenols (2,4- and 2,6-dichlorophenol, 2,4,5- and 2,4,6-trichlorophenol, 2,3,4,6-tetrachlorophenol and pentachlorophenol) were examined in V79 Chinese hamster cells without exogenous metabolic activation. |
31(0,1,1,1) | Details |
| 1496823 | Dulik DM, Huwe JK, Bakke JE, Connors MS, Fenselau C: Conjugation of polychlorinated agrochemical sulphoxides and sulphones by Xenobiotica. 1992 Mar;22(3):325-34. Protein was immobilized with greater than 95% transferase activity, measured by dinitrochlorobenzene. |
2(0,0,0,2) | Details |
| 7466831 | Debets FM, Strik JJ, Olie K: Effects of pentachlorophenol on rat liver changes induced by hexachlorobenzene, with special reference to porphyria, and alterations in mixed function oxygenases. Toxicology. 1980;15(3):181-95. Microsomal cytochrome P-450, -cytochrome c reductase, ethoxyresorufin O-de-ethylase, aminopyrine N-demethylase, and glucuronyl transferase increased to a maximum in 2-4 weeks in HCB and HCB + PCP fed rats. |
1(0,0,0,1) | Details |
| 8812277 | Umemura T, Sai-Kato K, Takagi A, Hasegawa R, Kurokawa Y: Oxidative DNA damage and cell proliferation in the livers of B6C3F1 mice exposed to pentachlorophenol in their diet. Fundam Appl Toxicol. 1996 Apr;30(2):285-9. Serum aspartic transferase activity at doses of 0.06% and above were significantly increased despite these changes being slight. |
1(0,0,0,1) | Details |
| 10771139 | Ait-Aissa S, Porcher J, Arrigo A, Lambre C: Activation of the hsp70 promoter by environmental inorganic and organic chemicals: relationships with cytotoxicity and lipophilicity. Toxicology. 2000 Apr 14;145(2-3):147-57. For this purpose, we used an established HeLa cell line containing the chloramphenicol acetyl transferase (CAT) gene under the control of the hsp70 promoter. |
1(0,0,0,1) | Details |
| 1995197 | Martire G, Villani GR, Della Morte R, Belisario MA, Pecce R, Staiano N: Effect of rat liver cytosolic enzymes and cofactors on mutagenicity of 1-amino-8-nitropyrene. Carcinogenesis. 1991 Feb;12(2):361-4. The addition to the mutagenesis assay of pentachlorophenol, an inhibitor of O-acetyltransferase and sulfotransferase, produced a dose-dependent decrease of 1,8-ANP mutagenic activation, whereas 2,6-dichloro- a more specific inhibitor of sulfotransferase than O-acetyltransferase, did not affect the activation of 1,8-ANP to a mutagen at concentrations that selectively inhibit only bacterial sulfotransferase. Addition of acetyl co-enzyme A (AcCoA) and 3'- 5'- cofactors for O-acetyl-transferase and sulfotransferase respectively, to the test system caused a dose-dependent inhibition of 1,8-ANP mutagenic activation by rat liver cytosol and probably due to the formation of highly reactive O-acetoxy and N- ester derivatives of 1,8-ANP, which react with nucleophilic sites before reaching bacterial DNA. |
1(0,0,0,1) | Details |