| Name | glutathione S transferase |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | pentachlorophenol |
|---|---|
| CAS | 2,3,4,5,6-pentachlorophenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8896715 | Moorthy B, Randerath K: Pentachlorophenol enhances 9-hydroxybenzo [a] pyrene-induced hepatic DNA adduct formation in vivo and inhibits microsomal epoxide hydrolase and glutathione S-transferase activities in vitro: likely inhibition of epoxide detoxication by pentachlorophenol. Arch Toxicol. 1996;70(11):696-703. |
82(1,1,1,2) | Details |
| 2865073 | LeBlanc GA, Cochrane BJ: Modulation of substrate-specific glutathione S-transferase activity in Daphnia magna with concomitant effects on toxicity tolerance. Comp Biochem Physiol C. 1985;82(1):37-42. |
2(0,0,0,2) | Details |
| 11437359 | Reddy GV, Gold MH: Purification and characterization of conjugate reductase: a component of the tetrachlorohydroquinone reductive dehalogenase system from Phanerochaete chrysosporium. Arch Biochem Biophys. 2001 Jul 15;391(2):271-7. A membrane-bound glutathione S-transferase and a soluble conjugate reductase constitute the reductive dehalogenase system of P. chrysosporium. This enzyme system reductively removes substituents from tetrachlorohydroquinone, a metabolite of pentachlorophenol. |
2(0,0,0,2) | Details |
| 1496823 | Dulik DM, Huwe JK, Bakke JE, Connors MS, Fenselau C: Conjugation of polychlorinated agrochemical sulphoxides and sulphones by Xenobiotica. 1992 Mar;22(3):325-34. Pentachlorophenyl methyl sulphoxide and pentachlorophenyl methyl sulphone were found to be substrates for microsomal and cytosolic glutathione-S-transferase of rabbit, monkey, chicken and human liver, covalently immobilized on beaded sepharose. 2. |
1(0,0,0,1) | Details |
| 11802731 | Kiefer PM Jr, McCarthy DL, Copley SD: The reaction catalyzed by tetrachlorohydroquinone dehalogenase does not involve nucleophilic aromatic substitution. Biochemistry. 2002 Jan 29;41(4):1308-14. Tetrachlorohydroquinone dehalogenase catalyzes the reductive dehalogenation of tetrachlorohydroquinone and trichlorohydroquinone during the biodegradation of the xenobiotic compound pentachlorophenol by Sphingobium chlorophenolicum. Tetrachlorohydroquinone dehalogenase is a member of the glutathione S-transferase superfamily. |
1(0,0,0,1) | Details |
| 8931562 | McCarthy DL, Navarrete S, Willett WS, Babbitt PC, Copley SD: Exploration of the relationship between tetrachlorohydroquinone dehalogenase and the glutathione S-transferase superfamily. Biochemistry. 1996 Nov 19;35(46):14634-42. Tetrachlorohydroquinone dehalogenase is found in Sphingomonas chlorophenolica, a soil bacterium that degrades pentachlorophenol, a widely used wood preservative. |
1(0,0,0,1) | Details |
| 11170506 | Gautier J, Richoz J, Welti DH, Markovic J, Gremaud E, Guengerich FP, Turesky RJ: Metabolism of ochratoxin A: absence of formation of genotoxic derivatives by human and rat enzymes. Chem Res Toxicol. 2001 Jan;14(1):34-45. The metabolism and covalent binding of OTA to DNA were investigated in vitro with cytochromes P450, glutathione S-transferases, prostaglandin H-synthase, and horseradish peroxidase. There was no evidence of DNA adduct formation when [(3) H] OTA was incubated with these enzyme systems in the presence of calf thymus DNA (<20 adducts/10 (9) DNA bases); however, these enzymes catalyzed DNA adduct formation with the genotoxins aflatoxin B (1), 2-amino-3-methylimidazo [4,5-f] quinoline, benzo [a] pyrene, and pentachlorophenol. |
1(0,0,0,1) | Details |
| 17355122 | Warner JR, Copley SD: Mechanism of the severe inhibition of tetrachlorohydroquinone dehalogenase by its aromatic substrates. Biochemistry. 2007 Apr 10;46(14):4438-47. Epub 2007 Mar 14. Tetrachlorohydroquinone (TCHQ) dehalogenase catalyzes the conversion of TCHQ to 2,6-dichlorohydroquinone during degradation of pentachlorophenol by Sphingobium chlorophenolicum. TCHQ dehalogenase is a member of the glutathione S-transferase superfamily. |
1(0,0,0,1) | Details |
| 18063032 | Zhang M, Yin D, Kong F: The changes of serum level and hepatic microsome enzyme activity of crucian carp (Carassius carassius) exposed to a sublethal dosage of pentachlorophenol. Ecotoxicol Environ Saf. 2008 Oct;71(2):384-9. Epub 2007 Dec 11. In this study, serum concentration, activity of liver microsome ethoxyresorufin O-deethylase (EROD) and glutathione S-transferases (GST) of crucian carp (Carassius carassius) exposed to PCP for 7 and 15 d, respectively, were examined. |
1(0,0,0,1) | Details |