| Name | HPRT |
|---|---|
| Synonyms | HGPRT; hPrt1; HGPRTase; HPRT; HPRT 1; HPRT1 protein; Hypoxanthine phosphoribosyltransferase 1; Hypoxanthine guanine phosphoribosyltransferase… |
| Name | pentachlorophenol |
|---|---|
| CAS | 2,3,4,5,6-pentachlorophenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2027344 | Jansson K, Jansson V: Induction of mutation in V79 Chinese hamster cells by tetrachlorohydroquinone, a metabolite of pentachlorophenol. Mutat Res. 1991 May;260(1):83-7. Tetrachlorohydroquinone (TCHQ) and tetrachlorocatechol (TCC), two metabolites of the environmental mutagen and carcinogen pentachlorophenol, were tested without exogenous activation in V79 Chinese hamster cells for the induction of mutation at the phosphoribosyl transferase (HPRT) locus to 6-thioguanine resistance (TGr) and at the Na/K-ATPase locus to ouabain resistance (OuaR). |
31(0,1,1,1) | Details |
| 11719101 | Purschke M, Jacobi H, Witte I: Differences in genotoxicity of H (2) O (2) and tetrachlorohydroquinone in human fibroblasts. Mutat Res. 2002 Jan 15;513(1-2):159-67. During autoxidation of the pentachlorophenol (PCP) metabolite tetrachlorohydroquinone (TCHQ) the semiquinone is formed as well as reactive oxygen species (ROS). In contrast to H (2) O (2), TCHQ in non-toxic concentrations was mutagenic in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus of V79 cells. |
1(0,0,0,1) | Details |