Protein Information

Name hemoglobin (protein family or complex)
Synonyms Hemoglobin; Hemoglobins

Compound Information

Name pentachlorophenol
CAS 2,3,4,5,6-pentachlorophenol

Reference List

PubMed Abstract RScore(About this table)
8728511 Waidyanatha S, Lin PH, Rappaport SM: Characterization of chlorinated adducts of hemoglobin and albumin following administration of pentachlorophenol to rats. Chem Res Toxicol. 1996 Apr-May;9(3):647-53.
32(0,1,1,2) Details
8870951 Wilson PM, La DK, Froines JR: Hemoglobin and DNA adduct formation in Fischer-344 rats exposed to 2,4- and 2,6-toluene diamine. Arch Toxicol. 1996;70(10):591-8.

The effects of metabolic inhibitors on adduct formation were examined using piperonyl butoxide and pentachlorophenol to inhibit p450 isozymes and sulfotransferase, respectively.
7(0,0,0,7) Details
8075381 Waidyanatha S, McDonald TA, Lin PH, Rappaport SM: Measurement of hemoglobin and albumin adducts of tetrachlorobenzoquinone. Chem Res Toxicol. 1994 May-Jun;7(3):463-8.

Tetrachloro-1,4-benzoquinone (Cl4BQ), a metabolite of pentachlorophenol (PCP), is believed to play a role in the genotoxicity of PCP.
2(0,0,0,2) Details
12415425 Tsai CH, Lin PH, Waidyanatha S, Rappaport SM: Fractionation of protein adducts in rats and mice dosed with [14C] pentachlorophenol. Arch Toxicol. 2002 Nov;76(11):628-33. Epub 2002 Sep 20.

Using a sequential scheme of scintillation counting along with selective cleavage of cysteinyl adducts by Raney nickel, we quantified total radiobinding, total covalent binding, non-cysteinyl protein binding, and specific protein adducts in liver nuclei (Np), liver cytosol (Cp), hemoglobin (Hb), and serum albumin (Alb).
1(0,0,0,1) Details
3265913 Oikari A, Linstrom-Seppa P, Kukkonen J: Subchronic metabolic effects and toxicity of a simulated pulp mill effluent on juvenile lake trout, Salmo trutta m. lacustris. Ecotoxicol Environ Saf. 1988 Dec;16(3):202-18.

In addition, a small (9%) but significant decrease in blood hemoglobin concentration was observed at the higher exposure concentration.
The greatest total gradient between bile and water CP was 5.2 X 10 (4) for pentachlorophenol.
1(0,0,0,1) Details