| Name | albumin |
|---|---|
| Synonyms | ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619… |
| Name | pentachlorophenol |
|---|---|
| CAS | 2,3,4,5,6-pentachlorophenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3994739 | Masini A, Ceccarelli-Stanzani D, Tomasi A, Trenti T, Ventura E: The role of pentachlorophenol in causing mitochondrial derangement in hexachlorobenzene induced experimental porphyria. Biochem Pharmacol. 1985 Apr 15;34(8):1171-4. |
0(0,0,0,0) | Details |
| 8397436 | Igisu H: [Binding of toxic substances and suppression of their toxicities by albumin--studies on and pentachlorophenol]. J UOEH. 1993 Sep 1;15(3):217-25. On the other hand, an artificial substance, pentachlorophenol (PCP), which is widely used for wood preservation, causes mitochondrial dysfunction and hemolysis in vitro, both of which can be suppressed by albumin. |
114(1,2,2,4) | Details |
| 8494778 | Igisu H: Haemolysis of human erythrocytes by pentachlorophenol and its suppression by albumin. Br J Ind Med. 1993 Apr;50(4):378-9. |
81(1,1,1,1) | Details |
| 12020603 | Seibert H, Morchel S, Gulden M: Factors influencing nominal effective concentrations of chemical compounds in vitro: medium protein concentration. Toxicol In Vitro. 2002 Jun;16(3):289-97. The fractions bound at 4% albumin varied between 11 and 15% for dextropropoxyphene and respectively, and more than 99% for hexachlorophene, pentachlorophenol and mercuric |
45(0,1,3,5) | Details |
| 12049848 | Gulden M, Morchel S, Tahan S, Seibert H: Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro. Toxicology. 2002 Jun 14;175(1-3):201-13. Calculated fractions bound to albumin in the normal growth medium were 0.075-0.17 (p,p'-DDT, p,p'-DDE, dieldrin, lindane), 0.09-0.1 (4-mono- and 0.68 (2,4,5-trichlorphenol) and almost 1.0 (pentachlorophenol). |
33(0,1,1,3) | Details |
| 8728511 | Waidyanatha S, Lin PH, Rappaport SM: Characterization of chlorinated adducts of hemoglobin and albumin following administration of pentachlorophenol to rats. Chem Res Toxicol. 1996 Apr-May;9(3):647-53. |
32(0,1,1,2) | Details |
| 12523958 | Gulden M, Morchel S, Seibert H: Serum albumin binding at cytotoxic concentrations of chemicals as determined with a cell proliferation assay. Toxicol Lett. 2003 Feb 3;137(3):159-68. The aim of the present study was to measure the influence of albumin binding on cytotoxic concentrations of chemicals and to determine binding parameters which can be used for quantitative in vitro-in vivo extrapolations. Increasing the BSA concentration either decreased the cytotoxic potency (12 compounds) by factors up to 34 (pentachlorophenol), had no effect (14 compounds), or increased the cytotoxicity (paraquat). |
3(0,0,0,3) | Details |
| 9049051 | Matsumura H, Matsuoka M, Igisu H, Ikeda M: Cooperative inhibition of acetylcholinesterase activities by hexachlorophene in human erythrocytes. Arch Toxicol. 1997;71(3):151-6. Hexachlorophene (HCP), pentachlorophenol (PCP), 2,4,5-trichlorophenol (2,4,5-TCP) and 2,4,6-trichlorophenol (2,4,6-TCP) all hemolyzed washed human erythrocytes and inhibited acetylcholinesterase (AchE) activities in erythrocyte membrane. The inhibition of AchE activities by HCP was reversed on adding albumin. |
2(0,0,0,2) | Details |
| 8075381 | Waidyanatha S, McDonald TA, Lin PH, Rappaport SM: Measurement of hemoglobin and albumin adducts of tetrachlorobenzoquinone. Chem Res Toxicol. 1994 May-Jun;7(3):463-8. Tetrachloro- (Cl4BQ), a metabolite of pentachlorophenol (PCP), is believed to play a role in the genotoxicity of PCP. |
2(0,0,0,2) | Details |
| 2393944 | van den Berg KJ: Interaction of chlorinated phenols with binding sites of human transthyretin, albumin and thyroid binding globulin. Chem Biol Interact. 1990;76(1):63-75. The ranking in competition was pentachlorophenol (PCP) greater than trichlorophenols greater than dichlorophenols greater than monochlorophenols. |
2(0,0,0,2) | Details |
| 6696763 | Masini A, Ceccarelli-Stanzani D, Trenti T, Rocchi E, Ventura E: Structural and functional properties of rat liver mitochondria in hexachlorobenzene induced experimental porphyria. Biochem Biophys Res Commun. 1984 Jan 13;118(1):356-63. By contrast a significant and constant uncoupling of the phosphorylative process, fully reversed by albumin, in mitochondria from rats treated with hexachlorobenzene and hexachlorobenzene plus iron has been presented. A possible involvement of pentachlorophenol in causing these abnormalities has been proposed. |
1(0,0,0,1) | Details |
| 9173 | Hoben HJ, Ching SA, Young RA, Casarett LJ: A study of the inhalation of pentachlorophenol by rats. Bull Environ Contam Toxicol. 1976 Aug;16(2):225-32. It also compared the albumin binding of PCP to the plasma binding of PCP for the rat and human. |
1(0,0,0,1) | Details |