| Name | carbonic anhydrase |
|---|---|
| Synonyms | CA IX; CA1; Carbonic anhydrase I; CA2; CAII; Carbonic anhydrase II; Carbonic dehydratase; Carbonic anhydrase III… |
| Name | diphenylamine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8447435 | Siga E, Mandon B, Roinel N, de Rouffignac C: Effects of calcitonin on function of intercalated cells of rat cortical collecting duct. Am J Physiol. 1993 Feb;264(2 Pt 2):F221-7. The CT-induced lumen-positive PDte was reduced by 2.3 +/- 0.8 mV after the basolateral addition of the Cl- channel inhibitor diphenylamine-2-carboxylate. 4-Acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid and acetazolamide, which inhibit Cl-/HCO3- exchangers and carbonic anhydrase activities, respectively, also inhibited the CT-induced PDte by 4.6 +/- 0.5 and 5.0 +/- 0.9 mV. |
81(1,1,1,1) | Details |
| 11875274 | Welsh MJ, Smith JJ: cAMP stimulation of HCO3- secretion across airway epithelia. JOP. 2001 Jul;2(4 Suppl):291-3. In addition, the cAMP-stimulated current was inhibited by the carbonic anhydrase inhibitor, acetazolamide, and by the apical addition of a blocker of cystic fibrosis transmembrane conductance regulator (CFTR), diphenylamine-2-carboxylate. |
31(0,1,1,1) | Details |
| 2411931 | Cuthbert AW, Hickman ME: Indirect effects of on secretion in mammalian colon. J Membr Biol. 1985;86(2):157-66. Using inhibitors of NaCl cotransport (piretanide), carbonic anhydrase (acetazolamide), and channels (diphenylamine-2-carboxylate), it was concluded that the SCC response to ATP was due to secretion with, perhaps, a minor contribution from |
31(0,1,1,1) | Details |
| 1313448 | Smith JJ, Welsh MJ: cAMP stimulates secretion across normal, but not cystic fibrosis airway epithelia. J Clin Invest. 1992 Apr;89(4):1148-53. Addition of forskolin stimulated an increase in short-circuit current that was likely a result of secretion because it was inhibited by a HCO3 (-)-free solution, by addition of the carbonic anhydrase inhibitor, acetazolamide, or by mucosal addition of the anion channel blocker, diphenylamine 2-carboxylate. |
31(0,1,1,1) | Details |
| 9662559 | Cheng HS, Leung PY, Cheng Chew SB, Leung PS, Lam SY, Wong WS, Wang ZD, Chan HC: Concurrent and independent HCO3- and Cl- secretion in a human pancreatic duct cell line (CAPAN-1). J Membr Biol. 1998 Jul 15;164(2):155-67. On the contrary, the HCO-3-dependent (in the absence of external Cl-) forskolin-induced Isc could be significantly reduced by carbonic anhydrase inhibitor, acetazolamide (45 microM). Apical addition of Cl- channel blocker, diphenylamine-2,2'-dicarboxylic acid (DPC, 1 mm), but not disulfonic acids, DIDS (100 microM) or SITS (100 microM), exerted an inhibitory effect on both Cl- and HCO-3-dependent forskolin-induced Isc responses. |
2(0,0,0,2) | Details |
| 9755067 | Breton S, Hammar K, Smith PJ, Brown D: secretion in the male reproductive tract: involvement of Cl--independent HCO-3 transport. Am J Physiol. 1998 Oct;275(4 Pt 1):C1134-42. We now show that PP-rich cells in the vas deferens express a high level of carbonic anhydrase type II (CAII) and that acetazolamide markedly inhibits the rate of secretion by 46.2 +/- 6.1%. In the presence of Cl-, diphenylamine-2-carboxylate (DPC) had no effect, whereas SITS inhibited secretion by 63.7 +/- 11.3% when applied together with DPC. |
2(0,0,0,2) | Details |
| 2848833 | Melvin JE, Moran A, Turner RJ: The role of HCO3- and Na+/H+ exchange in the response of rat parotid acinar cells to muscarinic stimulation. J Biol Chem. 1988 Dec 25;263(36):19564-9. The rate of this acidification was reduced by removal of exogenous HCO3- and by the carbonic anhydrase inhibitor methazolamide. Carbachol induced acidification was inhibited by the Cl- channel blocker diphenylamine 2-carboxylate but not by 4-acetomido-4'-isothiocyanostilbene-2,2'-disulfonic acid, an inhibitor of Cl-/HCO3- exchange. |
1(0,0,0,1) | Details |
| 2481726 | Brown PD, Elliott AC, Lau KR: Indirect evidence for the presence of non-specific anion channels in rabbit mandibular salivary gland acinar cells. J Physiol. 1989 Jul;414:415-31. The Cl- channel blockers diphenylamine-2-carboxylic acid (DPC, 1 mM) and 5-nitro-2-(3-phenylpropylamino)- (0.5 mM) abolished the -evoked acidosis in both HCO3 (-) -and -buffered media. 6. |
0(0,0,0,0) | Details |