Protein Information

Name catalase
Synonyms CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases…

Compound Information

Name diphenylamine
CAS

Reference List

PubMed Abstract RScore(About this table)
5385700 Shanmugam KT, Berger LR: Mechanism of catalase induction in Rhodopseudomonas spheroides: the effects of acridine, acriflavin, and diphenylamine. Arch Mikrobiol. 1969;69(3):206-15.
31(0,1,1,1) Details
9212351 Hu ML, Shih MK: Ascorbic acid inhibits lipid peroxidation but enhances DNA damage in rat liver nuclei incubated with iron ions. Free Radic Res. 1997 Jun;26(6):585-92.

The chain-breaking antioxidants butylated hydroxytoluene and diphenylamine (an alkoxyl radical scavenger) did not inhibit DNA damage.
Hydrogen peroxide and superoxide anions were also involved, as DNA damage was partially inhibited by catalase and, to a lesser extent, by superoxide dismutase.
1(0,0,0,1) Details
7800659 Pasquini R, Scassellati-Sforzolini G, Dolara P, Pampanella L, Villarini M, Caderni G, Fazi M, Fatigoni C: Assay of linuron and a pesticide mixture commonly found in the Italian diet, for promoting activity in rat liver carcinogenesis. Pharmacol Toxicol. 1994 Sep-Oct;75(3-4):170-6.

Composition of the pesticide mixture was: benomyl (19.55%); dithiocarbamates (20.67%); thiabendazole (14.94%); diphenylamine (14.25%); chlorthalonil (13.13%); procymidone (7.96%); fenarimol (1.95%); chlorpropham (0.70%); vinchlozolin (0.28%); methidathion (2.37%); chlorpyriphos-ethyl (2.09%); parathionmethyl (1.00%); chlorfenvinphos (0.27%); parathion (0.70%); pyrimiphos-ethyl (0.14%).
To determine promoting activity we evaluated induction of preneoplastic foci in diethylnitrosamine-initiated hepatocytes, by positive gammaglutamyl-transpeptidase (GGTase) staining in liver slides, and peroxisome proliferation by peroxisomal-dependent catalase and palmitoyl-CoA-oxidase dosage.
1(0,0,0,1) Details
10036333 Shih MK, Hu ML: UVA-induced oxidative damage to rat liver nuclei: reduction of iron ions and the relationship between lipid peroxidation and DNA damage. Mutat Res. 1999 Jan 13;438(2):125-32.


Inclusion of EDTA or chain-breaking antioxidants, butylated hydroxytoluene (BHT) and diphenylamine (an alkoxy radical scavenger), inhibited lipid peroxidation but not the level of 8-OH-dGu.
0(0,0,0,0) Details
8206871 Ohyashiki T, Sakata N, Matsui K: Changes in SH reactivity of the protein in porcine intestinal brush-border membranes associated with lipid peroxidation. J Biochem. 1994 Feb;115(2):224-9.


Pretreatment of the membranes with diphenylamine effectively prevented the ascorbic acid/Fe2+/t-BuOOH-induced decreases in the DACM-labeling and DPH incorporation rates, whereas neither superoxide dismutase, catalase, sodium benzoate, nor mannitol showed a protective effect.
0(0,0,0,0) Details
1259955 Wang HP, Kimura T: Ferrous ion-mediated cytochrome P-450 degradation and lipid peroxidation in adrenal cortex mitochondria. Biochim Biophys Acta. 1976 Mar 12;423(3):374-81.


Yet, diphenylamine proved to be a powerful inhibitor for both reactions, suggesting the involvement of a radical species.
0(0,0,0,0) Details