| Name | Lipoxygenase (protein family or complex) |
|---|---|
| Synonyms | arachidonate lipoxygenase; arachidonate lipoxygenases; lipoxygenase; lipoxygenases |
| Name | diphenylamine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1284079 | Kubo M, Okada Y: Volume-regulatory Cl- channel currents in cultured human epithelial cells. . J Physiol. 1992 Oct;456:351-71. The outward and inward currents were equally inhibited by a carboxylate analogue Cl- channel blocker, 5-nitro-2-(3-phenylpropylamino)- (NPPB) or diphenylamine-2-carboxylate (DPC) at higher doses (IC50 = 25 for NPPB or 350 microM for DPC). was still effective in the presence of inhibitors of lipoxygenase (nordihydroguaiaretic acid, 10 microM), cyclo-oxygenase (indomethacin, 10 microM) and protein kinase C (polymyxin B, 30 microM). |
1(0,0,0,1) | Details |
| 1443868 | Tamaoki J, Isono K, Chiyotani A, Kondo M, Konno K: Angiotensin II-1 receptor-mediated Cl secretion by canine tracheal epithelium. Am Rev Respir Dis. 1992 Nov;146(5 Pt 1):1187-91. Diphenylamine-2-carboxylate, Cl-free medium, indomethacin, the phospholipase A2 inhibitor mepacrine, and the methyltransferase inhibitor 3-deazaadenosine reduced the change in ISC, whereas amiloride and the lipoxygenase inhibitor AA-861 did not. |
31(0,1,1,1) | Details |
| 1375638 | Sakai H, Okada Y, Morii M, Takeguchi N: and activate small-conductance Cl- channels in the basolateral membrane of rabbit parietal cells. J Physiol. 1992 Mar;448:293-306. The combined application of a cyclo-oxygenase inhibitor, indomethacin (50 microM), and a lipoxygenase inhibitor, esculetin (100 microM), increased the Cl- current, whereas the administration of a phospholipase A2 inhibitor, mepacrine (100 microM), significantly decreased the whole-cell Cl- current. 6. Another Cl- channel blocker, 4-acetamido-4'-isothiocyanatostilbene-2,2'-dilsulphonic acid or diphenylamine-2-carboxylate was much less effective. 4. |
1(0,0,0,1) | Details |
| 7815759 | Kondo M, Tamaoki J, Konno K: [Cell-to-cell interaction in airway mucosa--effect of eosinophils on airway epithelial ion transport]. Nihon Kyobu Shikkan Gakkai Zasshi. 1994 Nov;32(11):1067-72. The response was inhibited by treatment of epithelial cells with diphenylamine-2-carboxylate but not by amiloride. The increase in Isc induced by the supermatant from eosinophils treated with indomethacin or the lipoxygenase inhibitor AA861 was significantly less than that induced by untreated eosinophils. |
1(0,0,0,1) | Details |
| 3112805 | Ohuchi K, Watanabe M, Fukui Y, Hirasawa N, Ozeki T, Tsurufuji S: The effect of diphenylamine derivatives on arachidonic acid metabolism in rat peritoneal macrophages. Prostaglandins Leukot Med. 1987 Jun;28(1):15-23. |
0(0,0,0,0) | Details |
| 1323920 | Tamaoki J, Kanemura T, Sakai N, Isono K, Chiyotani A, Yamauchi F, Takizawa T, Konno K: increases Cl secretion across canine tracheal epithelium through cyclo-oxygenase stimulation and cAMP production. Acta Physiol Scand. 1992 May;145(1):1-6. The -induced increase in Isc was not altered by preincubation of cells with autonomic antagonists (phentolamine, atropine), the lipoxygenase inhibitor AA-861, the protein kinase C inhibitor H-7, or the Na channel blocker amiloride, but it was inhibited by each of indomethacin, piroxicam, the Cl channel blocker diphenylamine-2-carboxylate, the Cl transport inhibitor and Cl-free medium. |
0(0,0,0,0) | Details |
| 1559589 | Tamaoki J, Isono K, Sakai N, Kanemura T, Konno K: Erythromycin inhibits Cl secretion across canine tracheal epithelial cells. Eur Respir J. 1992 Feb;5(2):234-8. The erythromycin-induced decrease in Isc was not altered by amiloride, but it was abolished by bumetanide, diphenylamine-2-carboxylate2, and substitution of Cl in the bathing medium with (p less than 0.001, in each case). |
0(0,0,0,0) | Details |