| Name | lactate dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | LDH; lactate dehydrogenase; lactate dehydrogenases |
| Name | allyl alcohol |
|---|---|
| CAS | 2-propen-1-ol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1999326 | Ganey PE, Keller B, Lichtman SN, Lemasters JJ, Thurman RG: A new method to monitor Kupffer cell phagocytosis continuously in perfused rat liver. Hepatology. 1991 Mar;13(3):567-74. This new method was combined with standard procedures to monitor parenchymal cell function (e.g., uptake and release of lactate dehydrogenase), Kupffer cell phagocytic activity and parenchymal cell injury simultaneously during perfusion with the hepatotoxicant allyl alcohol. |
31(0,1,1,1) | Details |
| 3746662 | Belinsky SA, Badr MZ, Kauffman FC, Thurman RG: Mechanism of hepatotoxicity in periportal regions of the liver lobule due to allyl alcohol: studies on thiols and energy status. J Pharmacol Exp Ther. 1986 Sep;238(3):1132-7. Infusion of allyl alcohol (350 microM) for 20 min depleted hepatic content by 95% in both regions of the liver lobule yet damage was undetectable as indexed by release of lactate dehydrogenase or uptake of trypan blue. |
13(0,0,2,3) | Details |
| 8571405 | Rikans LE, Cai DY, Hornbrook KR: Oxidation of nucleotides is an early event in the lethality of allyl alcohol. Toxicology. 1996 Jan 8;106(1-3):85-92. NAD+, and viability loss (leakage of lactate dehydrogenase into the medium) were measured in cells incubated with 0.5 mM allyl alcohol with or without the addition of 2 mM at 30 min. |
6(0,0,1,1) | Details |
| 3755756 | Badr MZ, Belinsky SA, Kauffman FC, Thurman RG: Mechanism of hepatotoxicity to periportal regions of the liver lobule due to allyl alcohol: role of and lipid peroxidation. J Pharmacol Exp Ther. 1986 Sep;238(3):1138-42. Infusion of allyl alcohol in -saturated perfusate in either direction caused release of lactate dehydrogenase and malondialdehyde. |
6(0,0,1,1) | Details |
| 2933316 | Belinsky SA, Bradford BU, Forman DT, Glassman EB, Felder MR, Thurman RG: Hepatotoxicity due to allyl alcohol in deermice depends on alcohol dehydrogenase. Hepatology. 1985 Nov-Dec;5(6):1179-82. In contrast, dose-dependent necrosis of periportal regions of the liver and increases in plasma levels of lactate dehydrogenase, sorbitol dehydrogenase and SGOT were observed in plasma from alcohol dehydrogenase-positive deermice (AdhF) 24 hr following administration of allyl alcohol (21 to 84 mg per kg). |
6(0,0,1,1) | Details |
| 7823323 | Rikans LE, Cai Y, Hornbrook KR: Allyl alcohol cytotoxicity in isolated rat hepatocytes: effects of azide, fasting, and J Toxicol Environ Health. 1995 Jan;44(1):1-11. ATP, ADP, AMP, and viability loss (leakage of lactate dehydrogenase into the medium) were measured in isolated hepatocytes of fed or fasted rats exposed to 0.5 mM allyl alcohol. |
6(0,0,1,1) | Details |
| 2835185 | Penttila KE: Allyl alcohol cytotoxicity and depletion in isolated periportal and perivenous rat hepatocytes. Chem Biol Interact. 1988;65(2):107-21. The distinct origin of the cell preparations was confirmed by the p.p./p.v. ratios of alanine aminotransferase (p.p./p.v. = 1.8), lactate dehydrogenase (1.3) and glutamine synthetase (0.10). |
2(0,0,0,2) | Details |
| 1871771 | te Koppele JM, Keller BJ, Caldwell-Kenkel JC, Lemasters JJ, Thurman RG: Effect of hepatotoxic chemicals and hypoxia on hepatic nonparenchymal cells: impairment of phagocytosis by Kupffer cells and disruption of the endothelium in rat livers perfused with colloidal carbon. Toxicol Appl Pharmacol. 1991 Aug;110(1):20-30. Therefore, the purpose of this study was to investigate the influence of several hepatotoxic chemicals (allyl alcohol, ethylhexanol, and and hypoxia on phagocytic activity of Kupffer cells in perfused rat liver. With all chemicals studied, a rapid (10-30 min) decline in the rate of phagocytosis preceded parenchymal cell death as assessed from release of lactate dehydrogenase. |
1(0,0,0,1) | Details |
| 6470978 | Belinsky SA, Popp JA, Kauffman FC, Thurman RG: Trypan blue uptake as a new method to investigate hepatotoxicity in periportal and pericentral regions of the liver lobule: studies with allyl alcohol in the perfused liver. J Pharmacol Exp Ther. 1984 Sep;230(3):755-60. Subsequently, lactate dehydrogenase began to appear in the effluent perfusate.(ABSTRACT TRUNCATED AT 250 WORDS) |
1(0,0,0,1) | Details |
| 11394714 | Karas M, Chakrabarti SK: potentiation of allyl alcohol-induced hepatotoxicity. J Environ Pathol Toxicol Oncol. 2001;20(2):155-64. The AA (2.5 mM)-induced lactate dehydrogenase (LDH) leakage observed after 60 minutes incubation was completely prevented when pretreated for 15 minutes with 4-methylpyrazole (MP) (0.5 mM). |
1(0,0,0,1) | Details |
| 3564024 | Smith PF, Fisher R, Shubat PJ, Gandolfi AJ, Krumdieck CL, Brendel K: In vitro cytotoxicity of allyl alcohol and bromobenzene in a novel organ culture system. Toxicol Appl Pharmacol. 1987 Mar 15;87(3):509-22. Dose- and time-dependent increases in media lactate dehydrogenase (LDH), and decreases in slice K+ content and in protein synthesis were observed in rat liver slices incubated with either compound at concentrations between 0.1 and 1 mM over a period of 6 hr. |
1(0,0,0,1) | Details |
| 3726883 | Rikans LE, Hornbrook KR: Isolated hepatocytes as a model for aging effects on hepatotoxicity: studies with allyl alcohol. Toxicol Appl Pharmacol. 1986 Jul;84(3):634-9. Initial values for trypan blue uptake, lactate dehydrogenase (LDH) release, alanine aminotransferase release, and content were similar in cells isolated from rats aged 5, 15, or 26 months. |
1(0,0,0,1) | Details |
| 1897958 | Lash LH, Woods EB: Cytotoxicity of alkylating agents in isolated rat kidney proximal tubular and distal tubular cells. Arch Biochem Biophys. 1991 Apr;286(1):46-56. Three model alkylating agents, methyl vinyl ketone, allyl alcohol, and N-dimethylnitrosamine, were used as test chemicals. Lactate dehydrogenase leakage was used to assess irreversible cellular injury. |
1(0,0,0,1) | Details |
| 1631894 | Przybocki JM, Reuhl KR, Thurman RG, Kauffman FC: Involvement of nonparenchymal cells in -dependent hepatic injury by allyl alcohol. Toxicol Appl Pharmacol. 1992 Jul;115(1):57-63. |
0(0,0,0,0) | Details |