Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name allyl alcohol
CAS 2-propen-1-ol

Reference List

PubMed Abstract RScore(About this table)
7169302 Fregnan GB, Frigerio L, Porta R, Prada M, Ruggieri F: Therapeutic properties of dihydroxy-dibutylether on sub-acute liver damage induced by several hepatotoxic agents in rats. Int J Tissue React. 1982;4(4):309-18.

In particular, four administrations of allyl alcohol, given every other day, increased glutamate oxaloacetate transaminase (GOT) for at least 48 hours from the last dose; ethionine reduced the bromsulphthalein (BSP) clearance even after 48 hours from the 1st, 2nd, or 3rd administration given on the 1st, 5th, or 12th day; ANIT, administered daily for seven days, increased glutamate pyruvate transaminase (GPT), alkaline phosphatase (AP), bilirubin, triglycerides (TG) and cholesterol (CH) while it decreased the body-weight and retarded growth for at least six to seven days after intoxication.
31(0,1,1,1) Details
6897138 Poole A, Chasseaud LF, Bridges JW: The effects of dimethylnitrosamine and allyl alcohol on primary maintenance cultures of adult rabbit hepatocytes. Toxicology. 1982;24(2):159-67.

By contrast, gamma-glutamyltranspeptidase and alkaline phosphatase were insensitive markers.
1(0,0,0,1) Details
7197952 Pagella PG, Faini D, Turba C: Effect of arginine thiazolidinecarboxylate on allyl alcohol hepatotoxicity in the rat. Arzneimittelforschung. 1981;31(9):1448-9.

Serum glutamic oxalacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and serum alkaline phosphatase (SAP) levels were estimated and gross and microscopic studies of the liver were performed.
1(0,0,0,1) Details
3008684 Wojcicki J, Hinek A, Samochowiec L: The protective effect of pollen extracts against allyl alcohol damage of the liver. Arch Immunol Ther Exp. 1985;33(6):841-9.

Liver damage was evaluated by measurement of aminotransferases (AspAT, AlAT) and alkaline phosphatase activity, total bilirubin level in the blood serum as well as by histological examination of the livers.
1(0,0,0,1) Details
8216823 Virtanen P, Lassila V, Soderstrom KO: Protoberberine alkaloids from Enantia chlorantha therapy of allyl-alcohol- and D-galactosamine-traumatized rats. Pathobiology. 1993;61(1):51-6.

There was a significant increase in serum alanine transferase (ALT) and serum alkaline phosphatase (APHOS) values induced by AA traumatization, which were lowered following Hepasor treatment.
1(0,0,0,1) Details
2741658 Virtanen P, Lassila V, Njimi T, Mengata DE: Effect of splenectomy on hepasor treatment in allyl-alcohol-traumatized rat liver. Acta Anat. 1989;134(4):301-4.

Biochemical assays from blood plasma, serum alanine transferase, serum alkaline phosphatase, serum creatinine, serum hydroxyproline and serum calcium were done and the total amount of blood obtained by decapitation was measured.
1(0,0,0,1) Details
6147091 Leonard TB, Neptun DA, Popp JA: Serum gamma glutamyl transferase as a specific indicator of bile duct lesions in the rat liver. Am J Pathol. 1984 Aug;116(2):262-9.


Single necrogenic doses of CCl4, allyl alcohol (AA), and alpha-naphthylisothiocyanate (ANIT) were used to produce cell specific injury in centrilobular hepatocytes, periportal hepatocytes, and bile duct cells, respectively.
0(0,0,0,0) Details