| Name | aspartate aminotransferase |
|---|---|
| Synonyms | Aspartate Aminotransferase 1; GIG18; GOT 1; GOT1; Aspartate aminotransferase; Glutamate oxaloacetate transaminase 1; Transaminase A; Aspartate aminotransferases… |
| Name | allyl alcohol |
|---|---|
| CAS | 2-propen-1-ol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1631894 | Przybocki JM, Reuhl KR, Thurman RG, Kauffman FC: Involvement of nonparenchymal cells in -dependent hepatic injury by allyl alcohol. Toxicol Appl Pharmacol. 1992 Jul;115(1):57-63. The extent of hepatic damage assessed by light microscopy and serum enzymes, aspartate aminotransferase and alanine aminotransferase, was markedly attenuated by pretreatment of rats with GdCl3 24 hr prior to allyl alcohol injection. |
6(0,0,1,1) | Details |
| 9169072 | Sneed RA, Grimes SD, Schultze AE, Brown AP, Ganey PE: Bacterial endotoxin enhances the hepatotoxicity of allyl alcohol. . Toxicol Appl Pharmacol. 1997 May;144(1):77-87. Rats were pretreated with LPS (100 micrograms/kg) 2 hr before treatment with a minimally toxic dose of allyl alcohol mg/kg), and liver toxicity was assessed 18 hr later from activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in plasma and from histologic changes in liver sections. |
6(0,0,1,1) | Details |
| 3999032 | Haddad P, Gascon-Barre M, Dumont A: Comparative hepatic response to bromobenzene and allyl alcohol in the -replete and -depleted rat. J Pharmacol Exp Ther. 1985 May;233(2):499-506. The severity of the hepatotoxicity was evaluated by the serum concentrations of aspartate aminotransferase, alanine aminotransferase and sorbitol dehydrogenase, the histomorphological appearance of the lesions, and the amount of cytochrome P-450 destroyed. |
1(0,0,0,1) | Details |
| 7905753 | Kress S, Katz N: Discrimination between periportal and pericentral necrosis of rat liver by determination of glutamine synthetase and other enzyme activities in serum. Eur J Clin Chem Clin Biochem. 1993 Nov;31(11):733-8. Periportal or pericentral necrosis of rat liver was produced by injection of allyl-alcohol or bromobenzene, respectively. Aspartate aminotransferase, which is more or less homogeneously distributed in the liver acinus, exhibited similar activities in serum after periportal and pericentral injury. |
1(0,0,0,1) | Details |
| 11446826 | Ganey PE, Barton YW, Kinser S, Sneed RA, Barton CC, Roth RA: Involvement of cyclooxygenase-2 in the potentiation of allyl alcohol-induced liver injury by bacterial lipopolysaccharide. Toxicol Appl Pharmacol. 2001 Jul 15;174(2):113-21. COX-2 mRNA was determined by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR), and liver injury was assessed from activities in serum of and aspartate aminotransferases (ALT and AST, respectively) and from histology. |
1(0,0,0,1) | Details |
| 10547960 | Wang RS, Nakajima T, Honma T: Different change patterns of the isozymes of cytochrome P450 and glutathione S-transferases in chemically induced liver damage in rat. Ind Health. 1999 Oct;37(4):440-8. Rats were administered 1,1-dichloroethylene (DCE), allyl alcohol (AA), bromobenzene (BB) and N,N-dimethylformamide (DMF) p.o. once every two days for 7 times, and decapitated 18 hr after the last administration. DCE and AA showed stronger hepatic toxicity than BB and DMF, as serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were higher in DCE and AA treated rats than in BB and DMF groups. |
1(0,0,0,1) | Details |
| 6710524 | Rikans LE: Influence of aging on the susceptibility of rats to hepatotoxic injury. Toxicol Appl Pharmacol. 1984 Apr;73(2):243-9. The effects of allyl alcohol, galactosamine, bromobenzene, and corn oil administration were evaluated in male Fischer 344 rats at 4 to 5, 14 to 15, and 24 to 25 months of age to determine if susceptibility to hepatotoxic injury is modified as a consequence of aging. Parameters measured were (1) severity of hepatocellular necrosis as judged by light microscopy of liver sections, (2) activity of alanine aminotransferase and aspartate aminotransferase in serum, and (3) hepatic microsomal cytochrome P-450 content and -cytochrome P-450 reductase activity. |
1(0,0,0,1) | Details |