| Name | glutathione S transferases |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | DBCP |
|---|---|
| CAS | 1,2-dibromo-3-chloropropane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7671343 | Soderlund EJ, Meyer DJ, Ketterer B, Nelson SD, Dybing E, Holme JA: Metabolism of 1,2-dibromo-3-chloropropane by glutathione S-transferases. . Chem Biol Interact. 1995 Aug 18;97(3):257-72. The metabolism of 1,2-dibromo-3-chloropropane (DBCP), measured as the formation of water soluble metabolites and metabolites covalently bound to macromolecules, was studied in isolated rat liver, kidney, and testicular cells, in subcellular fractions, and with purified rat and human glutathione S-transferases (GSTs). |
82(1,1,1,2) | Details |
| 7678904 | Becher R, Lag M, Schwarze PE, Brunborg G, Soderlund EJ, Holme JA: Chemically induced DNA damage in isolated rabbit lung cells. Mutat Res. 1993 Feb;285(2):303-11. The nematocide DBCP, activated by both P450- and glutathione S-transferase (s)-dependent pathways, caused considerably less DNA damage in macrophages than in Clara or type II cells. |
81(1,1,1,1) | Details |
| 8665617 | Brunborg G, Soderlund EJ, Holme JA, Dybing E: Organ-specific and transplacental DNA damage and its repair in rats treated with 1,2-dibromo-3-chloropropane. Chem Biol Interact. 1996 Jun;101(1):33-48. The data are also in accordance with glutathione-S-transferase, rather than P450, being the most important pathway for metabolic activation of DBCP in rat extrahepatic tissues including the fetal liver. |
81(1,1,1,1) | Details |
| 8242859 | Simula TP, Glancey MJ, Soderlund EJ, Dybing E, Wolf CR: Increased mutagenicity of 1,2-dibromo-3-chloropropane and tris (2,3-dibromopropyl) in Salmonella TA100 expressing human glutathione S-transferases. Carcinogenesis. 1993 Nov;14(11):2303-7. We have expressed human glutathione S-transferases GSTA1-1 and GSTP1-1 in Salmonella typhimurium TA100 in order to assess the ability of these enzymes to modulate the mutagenicity of 1,2-dibromo-3-chloropropane (DBCP) and tris (2,3-dibromopropyl) (Tris-BP). |
32(0,1,1,2) | Details |
| 2734806 | Lag M, Omichinski JG, Soderlund EJ, Brunborg G, Holme JA, Dahl JE, Nelson SD, Dybing E: Role of P-450 activity and levels in 1,2-dibromo-3-chloropropane tissue distribution, renal necrosis and in vivo DNA damage. Toxicology. 1989 Jun 16;56(3):273-88. Treatments known to alter P-450 activity and levels were used to elucidate the involvement of P-450 and glutathione S-transferase metabolism in 1,2-dibromo-3-chloropropane (DBCP) organ toxicity in the rat. |
31(0,1,1,1) | Details |
| 3537323 | Miller GE, Brabec MJ, Kulkarni AP: Mutagen activation of 1,2-dibromo-3-chloropropane by cytosolic glutathione S-transferases and microsomal enzymes. J Toxicol Environ Health. 1986;19(4):503-18. It is not clear whether (GSH) conjugation to 1,2-dibromo-3-chloropropane (DBCP) results in genotoxic activation. |
1(0,0,0,1) | Details |
| 7495641 | Kouzi SA, Soderlund EJ, Dybing E, Meerman JH, Nelson SD: Comparative toxicity of (+)-(R)- and (-)-(S)-1,2-dibromo-3-chloropropane. Chirality. 1995;7(5):359-64. The haloalkane 1,2-dibromo-3-chloropropane (DBCP), an environmental pollutant that was widely used as a soil fumigant, is a carcinogen and a mutagen and displays target-organ toxicity to the testes and the kidneys. |
0(0,0,0,0) | Details |