Protein Information

Name transferase
Synonyms 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80…

Compound Information

Name DBCP
CAS 1,2-dibromo-3-chloropropane

Reference List

PubMed Abstract RScore(About this table)
6376058 MacFarland RT, Gandolfi AJ, Sipes IG: Extra-hepatic GSH-dependent metabolism of 1,2-dibromoethane (DBE) and 1,2-dibromo-3-chloropropane (DBCP) in the rat and mouse. Drug Chem Toxicol. 1984;7(3):213-27.

Rates of metabolism for DBE and DBCP represented only a small fraction of the total cytosolic GSH S-transferase activity.
31(0,1,1,1) Details
1794113 Holme JA, Soderlund EJ, Brunborg G, Lag M, Nelson SD, Dybing E: DNA damage and cell death induced by 1,2-dibromo-3-chloropropane (DBCP) and structural analogs in monolayer culture of rat hepatocytes: 3-aminobenzamide inhibits the toxicity of DBCP. Cell Biol Toxicol. 1991 Oct;7(4):413-32.

The addition of the proposed specific poly (ADP-ribosyl) transferase inhibitor 3-aminobenzamide (3-ABA) protected against DBCP-induced cytotoxic effects and NAD+ depletion.
31(0,1,1,1) Details
2620797 Heindel JJ, Berkowitz AS, Kyle G, Luthra R, Bruckner JV: Assessment in rats of the gonadotoxic and hepatorenal toxic potential of dibromochloropropane (DBCP) in drinking water. Fundam Appl Toxicol. 1989 Nov;13(4):804-15.

Blood samples were taken after 2, 4, and 6 weeks of exposure and at the terminal sacrifice and assayed for serum glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, sorbitol dehydrogenase, and ornithine-carbamyl transferase activities and BUN levels.
1(0,0,0,1) Details