| Name | hypoxanthine guanine phosphoribosyltransferase |
|---|---|
| Synonyms | HGPRT; hPrt1; HGPRTase; HPRT; HPRT 1; HPRT1 protein; Hypoxanthine phosphoribosyltransferase 1; Hypoxanthine guanine phosphoribosyltransferase… |
| Name | furfural |
|---|---|
| CAS | 2-furancarboxaldehyde |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8075362 | Surh YJ, Tannenbaum SR: Activation of the Maillard reaction product 5-(hydroxymethyl) furfural to strong mutagens via allylic sulfonation and chlorination. Chem Res Toxicol. 1994 May-Jun;7(3):313-8. In support of this concept, the chemically synthesized sulfuric acid ester,5-[(sulfooxy)-methyl] furfural (SMF), exhibited direct mutagenicity at both thymidine kinase and hypoxanthine-guanine phosphoribosyltransferase loci in human lymphoblasts. |
31(0,1,1,1) | Details |
| 10930701 | Janzowski C, Glaab V, Samimi E, Schlatter J, Eisenbrand G: 5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione. Food Chem Toxicol. 2000 Sep;38(9):801-9. 5-(hydroxymethyl)-2-furfural (HMF), a common product of the Maillard reaction, occurs in many foods in high concentrations, sometimes exceeding 1 g/kg (in certain dried fruits and caramel products). To elucidate the toxic potential of HMF, cytotoxicity (trypan blue exclusion), growth inhibition (SRB assay), mutagenicity (HPRT assay), DNA damage (single-cell gel electrophoresis) and depletion of cellular were investigated in mammalian cells. |
1(0,0,0,1) | Details |