Protein Information

Name beta glucosidase
Synonyms CBG; CBG; GLUC; CBGL 1; CBGL1; Cytosolic beta glucosidase; Cytosolic beta glucosidase like protein 1; GBA 3…

Compound Information

Name furfural
CAS 2-furancarboxaldehyde

Reference List

PubMed Abstract RScore(About this table)
11069006 Szengyel Z, Zacchi G: Effect of acetic acid and furfural on cellulase production of Trichoderma reesei RUT C30. Appl Biochem Biotechnol. 2000 Oct;89(1):31-42.

Furfural proved to be an inhibiting agent causing a significant decrease in both cellulase and beta-glucosidase production.
83(1,1,1,3) Details
19119005 Zhu JY, Pan XJ, Wang GS, Gleisner R: Sulfite pretreatment (SPORL) for robust enzymatic saccharification of spruce and red pine. Bioresour Technol. 2009 Apr;100(8):2411-8. Epub 2008 Dec 31.

The results indicated that after the SPORL pretreatment of spruce chips with 8-10% bisulfite and 1.8-3.7% sulfuric acid on oven dry (od) wood at 180 degrees C for 30 min, more than 90% cellulose conversion of substrate was achieved with enzyme loading of about 14.6 FPU cellulase plus 22.5 CBU beta-glucosidase per gram of od substrate after 48 h hydrolysis.
Furthermore, the SPORL produced low amounts of fermentation inhibitors, hydroxymethyl furfural (HMF) and furfural, of about 5 and 1 mg/g of untreated od wood, respectively.
1(0,0,0,1) Details
14763843 Cantarella M, Cantarella L, Gallifuoco A, Spera A, Alfani F: Effect of inhibitors released during steam-explosion treatment of poplar wood on subsequent enzymatic hydrolysis and SSF. Biotechnol Prog. 2004 Jan-Feb;20(1):200-6.

The enzyme activities for endo-glucanase, exo-glucanase, and beta-glucosidase were 5.76, 0.55, and 5.98 U/mg, respectively.
The inhibiting effects of components released during SE (formic, acetic, and levulinic acids, furfural, 5-hydroxymethyl furfural (5-HMF), syringaldehyde, 4-hydroxy benzaldehyde, and vanillin) were studied at different concentrations in hydrolysis runs performed with rinsed SE biomass as model substrate.
1(0,0,0,1) Details
12207497 Yokozawa T, Kim HY, Cho EJ, Choi JS, Chung HY: Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes. J Agric Food Chem. 2002 Sep 11;50(19):5490-5.

Oral administration of isorhamnetin diglucoside (10 or 20 mg/kg of body weight/day for 10 days) to rats with streptozotocin-induced diabetes significantly reduced serum levels of glucose and 5-(hydroxymethyl) furfural (5-HMF), which is glycosylated with hemoglobin and is an indicator of oxidative stress.
On the basis of the oral and intraperitoneal results, it was hypothesized that isorhamnetin diglucoside was converted to its metabolite in vivo, and its conversion to its aglycone, isorhamnetin, by beta-glucosidase was confirmed; isorhamnetin acted as an antioxidant.
1(0,0,0,1) Details
16599561 Saha BC, Cotta MA: Ethanol production from alkaline peroxide pretreated enzymatically saccharified wheat straw. Biotechnol Prog. 2006 Mar-Apr;22(2):449-53.

The maximum yield of monomeric sugars from wheat straw (8.6%, w/v) by alkaline peroxide pretreatment (2.15% H (2) O (2), v/v; pH 11.5; 35 degrees C; 24 h) and enzymatic saccharification (45 degrees C, pH 5.0, 120 h) by three commercial enzyme preparations (cellulase, beta-glucosidase, and xylanase) using 0.16 mL of each enzyme preparation per g of straw was 672 +/- 4 mg/g (96.7% yield).
During the pretreatment, no measurable quantities of furfural and hydroxymethyl furfural were produced.
1(0,0,0,1) Details
19551888 Wang GS, Pan XJ, Zhu JY, Gleisner R, Rockwood D: Sulfite pretreatment to overcome recalcitrance of lignocellulose (SPORL) for robust enzymatic saccharification of hardwoods. Biotechnol Prog. 2009 Jul-Aug;25(4):1086-93.

The enzyme loading was about 20 FPU cellulase plus 30 CBU beta-glucosidase per gram of cellulose.
The production of fermentation inhibitor furfural was less than 20 mg/g of aspen wood at pH 4.5.
1(0,0,0,1) Details
18835157 Gupta R, Sharma KK, Kuhad RC: Separate hydrolysis and fermentation (SHF) of Prosopis juliflora, a woody substrate, for the production of cellulosic ethanol by Saccharomyces cerevisiae and Pichia stipitis-NCIM 3498. Bioresour Technol. 2009 Feb;100(3):1214-20. Epub 2008 Oct 2.

Dilute H (2) SO (4) (3.0%,v/v) treatment resulted in hydrolysis of hemicelluloses from lignocellulosic complex to pentose sugars along with other byproducts such as furfural, hydroxymethyl furfural (HMF), phenolics and acetic acid.
The remaining cellulosic residue was enzymatically hydrolyzed in 0.05 M citrate phosphate buffer (pH 5.0) using 3.0 U of filter paper cellulase (FPase) and 9.0 U of beta-glucosidase per mL of citrate phosphate buffer.
1(0,0,0,1) Details
15932261 Saha BC, Iten LB, Cotta MA, Wu YV: Dilute acid pretreatment, enzymatic saccharification, and fermentation of rice hulls to ethanol. Biotechnol Prog. 2005 May-Jun;21(3):816-22.

The maximum yield of monomeric sugars from rice hulls (15%, w/v) by dilute H2SO4 (1.0%, v/v) pretreatment and enzymatic saccharification (45 degrees C, pH 5.0, 72 h) using cellulase, beta-glucosidase, xylanase, esterase, and Tween 20 was 287 +/- 3 mg/g (60% yield based on total carbohydrate content).
Under this condition, no furfural and hydroxymethyl furfural were produced.
1(0,0,0,1) Details