Protein Information

Name alcohol dehydrogenase 6
Synonyms ADH 6; ADH6; ADH6 protein; Alcohol dehydrogenase 6; alcohol dehydrogenase 6 (class V); ADH6 proteins; Alcohol dehydrogenase 6s; alcohol dehydrogenase 6 (class V)s

Compound Information

Name furfural
CAS 2-furancarboxaldehyde

Reference List

PubMed Abstract RScore(About this table)
16652391 Petersson A, Almeida JR, Modig T, Karhumaa K, Hahn-Hagerdal B, Gorwa-Grauslund MF, Liden G: A 5-hydroxymethyl furfural reducing enzyme encoded by the Saccharomyces cerevisiae ADH6 gene conveys HMF tolerance. Yeast. 2006 Apr 30;23(6):455-64.
83(1,1,1,3) Details
18330568 Almeida JR, Roder A, Modig T, Laadan B, Liden G, Gorwa-Grauslund MF: NADH- vs NADPH-coupled reduction of 5-hydroxymethyl furfural (HMF) and its implications on product distribution in Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2008 Apr;78(6):939-45. Epub 2008 Mar 11.

In the present study, strains overexpressing the corresponding genes (mut-ADH1 and ADH6), together with a control strain, were compared in defined medium for anaerobic fermentation of glucose in the presence and absence of HMF.
5(0,0,0,5) Details
19925001 Kostesha NV, Almeida JR, Heiskanen AR, Gorwa-Grauslund MF, Hahn-Hagerdal B, Emneus J: Electrochemical probing of in vivo 5-hydroxymethyl furfural reduction in Saccharomyces cerevisiae. Anal Chem. 2009 Dec 15;81(24):9896-901.

Cells overexpressing the alcohol dehydrogenase 6 gene (ADH6 strain) and cells carrying the corresponding control plasmid (control strain) were each immobilized on Au-microelectrodes.
3(0,0,0,3) Details
19506862 Almeida JR, Bertilsson M, Hahn-Hagerdal B, Liden G, Gorwa-Grauslund MF: Carbon fluxes of xylose-consuming Saccharomyces cerevisiae strains are affected differently by NADH and NADPH usage in HMF reduction. Appl Microbiol Biotechnol. 2009 Sep;84(4):751-61. Epub 2009 Jun 9.

The furaldehydes 5-hydroxymethyl-furfural (HMF) and furfural inhibit yeast metabolism, prolong the lag phase, and reduce the ethanol productivity.
Then, the genes encoding the NADH- and the NADPH-dependent HMF reductases, ADH1-S110P-Y295C and ADH6, respectively, were individually overexpressed in this background.
1(0,0,0,1) Details