| 16405901 |
Mizushina Y, Yagita E, Kuramochi K, Kuriyama I, Shimazaki N, Koiwai O, Uchiyama Y, Yomezawa Y, Sugawara F, Kobayashi S, Sakaguchi K, Yoshida H: 5-(Hydroxymethyl)-2-furfural: a selective inhibitor of DNA polymerase lambda and terminal deoxynucleotidyltransferase. Arch Biochem Biophys. 2006 Feb 1;446(1):69-76. Epub 2005 Dec 15.
5-(Hydroxymethyl)-2-furfural (HMF), a pyrolysate of carbohydrate isolated from instant coffee (Coffea arabica L.), selectively inhibits the activities of mammalian DNA polymerase lambda (pol lambda) and terminal deoxynucleotidyltransferase (TdT) which are family X pols, in vitro. |
85(1,1,1,5) |
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