Protein Information

Name alcohol dehydrogenase (protein family or complex)
Synonyms ADH; alcohol dehydrogenase; alcohol dehydrogenases

Compound Information

Name furfural
CAS 2-furancarboxaldehyde

Reference List

PubMed Abstract RScore(About this table)
18330568 Almeida JR, Roder A, Modig T, Laadan B, Liden G, Gorwa-Grauslund MF: NADH- vs NADPH-coupled reduction of 5-hydroxymethyl furfural (HMF) and its implications on product distribution in Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2008 Apr;78(6):939-45. Epub 2008 Mar 11.

Saccharomyces cerevisiae alcohol dehydrogenases responsible for NADH-, and NADPH-specific reduction of the furaldehydes 5-hydroxymethyl-furfural (HMF) and furfural have previously been identified.
81(1,1,1,1) Details
19363068 Lin FM, Qiao B, Yuan YJ: Comparative proteomic analysis of tolerance and adaptation of ethanologenic Saccharomyces cerevisiae to furfural, a lignocellulosic inhibitory compound. Appl Environ Microbiol. 2009 Jun;75(11):3765-76. Epub 2009 Apr 10.

These observations indicate that central carbon metabolism, levels of alcohol dehydrogenases, and the redox balance may be related to tolerance of ethanologenic yeast for and adaptation to furfural.
32(0,1,1,2) Details
16233216 Roustan JL, Sablayrolles JM: Modification of the acetaldehyde concentration during alcoholic fermentation and effects on fermentation kinetics. J Biosci Bioeng. 2002;93(4):367-75.

We also modulated the acetaldehyde concentration by modifying the alcohol dehydrogenase-catalyzed reaction.
Two approaches were tested (i) adding aldehydes (propanal and furfural) that competitively inhibited the reduction of acetaldehyde and (ii) adding electron acceptors that reduced the quantity of NADH available.
1(0,0,0,1) Details
11964178 Modig T, Liden G, Taherzadeh MJ: Inhibition effects of furfural on alcohol dehydrogenase, aldehyde dehydrogenase and pyruvate dehydrogenase. Biochem J. 2002 May 1;363(Pt 3):769-76.
162(2,2,2,2) Details