Protein Information

Name hemoglobin (protein family or complex)
Synonyms Hemoglobin; Hemoglobins

Compound Information

Name furfural
CAS 2-furancarboxaldehyde

Reference List

PubMed Abstract RScore(About this table)
15341482 Safo MK, Abdulmalik O, Danso-Danquah R, Burnett JC, Nokuri S, Joshi GS, Musayev FN, Asakura T, Abraham DJ: Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds. J Med Chem. 2004 Sep 9;47(19):4665-76.

Naturally occurring five-membered heterocyclic aldehydes, including 5-hydroxymethyl-2-furfural, increase the oxygen affinity of hemoglobin (Hb) and strongly inhibit the sickling of homozygous sickle red blood (SS) cells.
82(1,1,1,2) Details
12207497 Yokozawa T, Kim HY, Cho EJ, Choi JS, Chung HY: Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes. J Agric Food Chem. 2002 Sep 11;50(19):5490-5.

Oral administration of isorhamnetin diglucoside (10 or 20 mg/kg of body weight/day for 10 days) to rats with streptozotocin-induced diabetes significantly reduced serum levels of glucose and 5-(hydroxymethyl) furfural (5-HMF), which is glycosylated with hemoglobin and is an indicator of oxidative stress.
81(1,1,1,1) Details
3236330 Hoberman HD, San George RC: Reaction of tobacco smoke aldehydes with human hemoglobin. . J Biochem Toxicol. 1988 Summer;3:105-19.

Mass spectrometric and HPLC analyses of the 2,4-dinitrophenylhydrazones precipitated from the condensate documented the presence of formaldehyde, acetaldehyde, propionaldehyde, butyraldehyde, furfural, and methylfurfural.
6(0,0,0,6) Details
7226519 Nayak SS, Pattabiraman TN: A new colorimetric method for the estimation of glycosylated hemoglobin. . Clin Chim Acta. 1981 Feb 5;109(3):267-74.

Hemolyzates were treated with 1 mol/l oxalic acid in 2 mol/l Hcl for 4 h at 100 degrees C, the protein was precipitated with trichloroacetic acid, and the free sugars and hydroxymethyl furfural in the protein free supernatant were treated with phenol and sulphuric acid to form the color.
4(0,0,0,4) Details
7180347 Boulton AJ, Hardisty CA, Worth RC, Drury J, Ward JD: Elevated glycosylated hemoglobin in diabetic neuropathy. . Acta Diabetol Lat. 1982 Oct-Dec;19(4):345-9.

A semi-automated colorimetric technique, employing the reaction between thiobarbituric acid and 5-hydroxy-methyl furfural, was used for the estimation of GHb.
2(0,0,0,2) Details
18948853 Villela NR, Cabrales P, Tsai AG, Intaglietta M: Microcirculatory effects of changing blood hemoglobin oxygen affinity during hemorrhagic shock resuscitation in an experimental model. Shock. 2009 Jun;31(6):645-52.

Allosteric effectors inositol hexaphosphate and 5-hydroxymethyl-2-furfural were introduced into the RBCs by electroporation to decrease and increase Hb-oxygen affinity.
2(0,0,0,2) Details
11464664 Costa MJ, Moraes LH, Bion FM, Rivera MA, Moura LS, Conceicao ML: [Efficacy evaluation of the molasses supplementation in normal and depleted rats diet]. Arch Latinoam Nutr. 2000 Dec;50(4):341-5.

Considering the possible deleterious effects of a high sugar diet, that can originate furfural during food processing, it is necessary to conduct more studies to evaluate the utilization of these products for human consumption.
The efficacy of molasses added to the diet of normal and depleted laboratory animals on growth and hemoglobin was tested.
2(0,0,0,2) Details
3985326 Lever M, May PC, Andre CM: Automated fluorimetric determination of furfurals. Anal Biochem. 1985 Jan;144(1):6-14.

Hydroxymethylfurfural and furfural can be estimated automatically at 60 samples/h in a continuous-flow system.
The procedure has applications for estimating the extent of hemoglobin glycosylation and for measuring the levels of hydroxymethylfurfural in some beverages.
1(0,0,0,1) Details
1704959 Kovaleva GG, Gorodetskii VK: [The effect of sorbitol on the determination of keto amines using a colorimetric method]. Lab Delo. 1990;(11):50-2.

Such sorbitol concentration has no effect on furfural production and on 5-hydroxymethylfurfural reaction with thiobarbituric acid.
Measurements of glycolyzed hemoglobin have demonstrated that sorbitol in concentration 11 mg/ml completely inhibits hydrolysis.
1(0,0,0,1) Details
17884988 Cabrales P, Tsai AG, Intaglietta M: Modulation of perfusion and oxygenation by red blood cell oxygen affinity during acute anemia. Am J Respir Cell Mol Biol. 2008 Mar;38(3):354-61. Epub 2007 Sep 20.

Responses to exchange transfusion using red blood cells (RBCs) with modified hemoglobin (Hb) oxygen (O (2)) affinity were studied in the hamster window chamber model during acute anemia to determine its role on microvascular perfusion and tissue oxygenation.
Inositol hexaphosphate (IHP) and 5-hydroxymethyl-2-furfural (5HMF) were used to decrease and increase Hb-O (2) affinity.
1(0,0,0,1) Details