| Name | T cell receptor (protein family or complex) |
|---|---|
| Synonyms | T cell Receptor; T cell Receptors |
| Name | OCH |
|---|---|
| CAS | 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18698251 | Haeryfar SM, Lan Z, Leon-Ponte M, Duffy KR, Ge W, Liu W, Mele T, Garcia B, Wang H: Prolongation of cardiac allograft survival by rapamycin and the invariant natural killer T cell glycolipid agonist OCH. Transplantation. 2008 Aug 15;86(3):460-8. Allografts were recovered on postoperative day 8 or at endpoint, stained with hematoxylin-eosin, and analyzed for intragraft transcript levels of effector cytokines and iNKT cells' invariant T-cell receptor segment Valpha14-Jalpha18. |
2(0,0,0,2) | Details |
| 15746081 | Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, Miyake S, Wakasugi H, Yamamura T, Kronenberg M, Raulet DH, Kinoshita K, Yagita H, Smyth MJ, Okumura K: IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2. Blood. 2005 Jul 1;106(1):184-92. Epub 2005 Mar 3. Activation of invariant natural killer T (iNKT) cells with CD1d-restricted T-cell receptor (TCR) ligands is a powerful means to modulate various immune responses. |
1(0,0,0,1) | Details |
| 14965307 | Yamamura T, Miyamoto K, Illes Z, Pal E, Araki M, Miyake S: NKT cell-stimulating synthetic glycolipids as potential therapeutics for autoimmune disease. Curr Top Med Chem. 2004;4(5):561-7. They are unique in their homogeneous ligand specificity for alpha-glycosylated sphingolipid and secrete large amounts of regulatory cytokines shortly after T cell receptor (TCR) engagement. |
1(0,0,0,1) | Details |
| 15173890 | Oki S, Chiba A, Yamamura T, Miyake S: The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells. J Clin Invest. 2004 Jun;113(11):1631-40. Furthermore, IFN-gamma production by NKT cells requires longer T cell receptor stimulation than is required for IL-4 production by NKT cells stimulated either with immobilized mAb to CD3 or with immobilized "alphaGC-loaded" CD1d molecules. |
1(0,0,0,1) | Details |
| 15860372 | Berkers CR, Ovaa H: Immunotherapeutic potential for -based activators of iNKT cells. Trends Pharmacol Sci. 2005 May;26(5):252-7. The alpha-GalCer analogs OCH and the recently designed and synthesized C-glycosidic alpha-GalCer selectively activate one of two types of cytokine profiles, possibly because either reduced or enhanced overall stability of the CD1d-glycolipid-T-cell-receptor complex leads to a higher potency in vivo, compared with the parent compound. |
1(0,0,0,1) | Details |