| 11931646 |
Crljen V, Volinia S, Banfic H: Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes. Biochem J. 2002 Aug 1;365(Pt 3):791-9.
Whereas in BLM rapid increases in 1,2-diacylglycerol, PtdIns (3,4,5) P (3) and PtdIns (3,4) P (2) were observed, suggesting that in BLM HGF activates both phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K), in BBM only HGF-induced transient accumulation of PtdIns3P was seen, which was temporarily delayed from signalling events in BLM and could be blocked by the PtdIns-specific-PLC inhibitor ET-18-OCH (3) and the calpain inhibitor calpeptin, suggesting that 3-kinase activation in BBM lies downstream of PLC activation in BLM and is a calpain-mediated event. |
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