| Name | caspase (protein family or complex) |
|---|---|
| Synonyms | caspase; caspases |
| Name | OCH |
|---|---|
| CAS | 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10552970 | Cuvillier O, Mayhew E, Janoff AS, Spiegel S: Liposomal ET-18-OCH (3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling. Blood. 1999 Nov 15;94(10):3583-92. We found that ELL-12 induced apoptosis in Jurkat, H9, and U-937 cells that was preceded by activation of executioner caspases. |
2(0,0,0,2) | Details |
| 10834929 | Bae SS, Perry DK, Oh YS, Choi JH, Galadari SH, Ghayur T, Ryu SH, Hannun YA, Suh PG: Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells. FASEB J. 2000 Jun;14(9):1083-92. Cleavage of PLC-gamma1 was blocked by overexpression of Bcl-2 and by specific inhibitors of caspases such as Z-DEVD-CH (2) F and YVAD-cmk. |
2(0,0,0,2) | Details |
| 12401552 | Kitamura Y, Inden M, Miyamura A, Kakimura J, Taniguchi T, Shimohama S: Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells. Neurosci Lett. 2002 Nov 15;333(1):25-8. |
2(0,0,0,2) | Details |
| 10738248 | Gajate C, Santos-Beneit AM, Macho A, Lazaro M, Hernandez-De Rojas A, Modolell M, Munoz E, Mollinedo F: Involvement of mitochondria and caspase-3 in ET-18-OCH (3)-induced apoptosis of human leukemic cells. Int J Cancer. 2000 Apr 15;86(2):208-18. Cyclosporin A partially inhibited DeltaPsi (m) dissipation, caspase activation and apoptosis in ET-18-OCH (3)-treated leukemic cells. |
2(0,0,0,2) | Details |
| 11919192 | Sitailo LA, Tibudan SS, Denning MF: Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes. J Biol Chem. 2002 May 31;277(22):19346-52. Epub 2002 Mar 27. These results identify caspase-9 as the critical upstream caspase initiating apoptosis by UV radiation in human keratinocytes, the relevant cell type for this important environmental carcinogen. |
1(0,0,0,1) | Details |
| 12605983 | Dai S, Huang ML, Hsu CY, Chao KS: Inhibition of hypoxia inducible factor 1alpha causes -independent cytotoxicity and induces p53 independent apoptosis in glioblastoma cells. Int J Radiat Oncol Biol Phys. 2003 Mar 15;55(4):1027-36. Pretreatment of cells with Z-Val--Asp (-OCH (3))-fluoromethylketone (Z-VAD), a broad-spectrum caspase inhibitor largely eliminated this effect of AS-HIF. |
1(0,0,0,1) | Details |
| 12890888 | Kitamura Y, Miyamura A, Takata K, Inden M, Tsuchiya D, Nakamura K, Taniguchi T: Possible involvement of both endoplasmic reticulum-and mitochondria-dependent pathways in thapsigargin-induced apoptosis in human neuroblastoma SH-SY5Y cells. J Pharmacol Sci. 2003 Jul;92(3):228-36. In addition, the degradation of caspases-9 and -3, cleavage of poly (ADP- polymerase, DNA fragmentation, and cell death were also observed. |
1(0,0,0,1) | Details |