Protein Information

Name thiopurine S methyltransferase
Synonyms 6 Mercaptopurine sensitivity; TPMT; Thiopurine S methyltransferase; Thiopurine methyltransferase; Thiopurine S methyltransferases; Thiopurine methyltransferases

Compound Information

Name OCH
CAS 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one

Reference List

PubMed Abstract RScore(About this table)
10707497 Lowhagen GB, Lindstedt G: [Bone marrow depression after azathioprine. Lakartidningen. 2000 Feb 2;97(5):458-62.


This may be caused by unexpectedly high concentrations of cytotoxic metabolites due to abnormally slow inactivation of 6-mercaptopurine (6-MP) by thiopurine S-methyltransferase (TPMT) and/or xanthine oxidase.
3(0,0,0,3) Details