| Name | IL 10 |
|---|---|
| Synonyms | B TCGF; B cell derived T cell growth factor; CSIF; Cytokine synthesis inhibitory factor; IL 10; IL10; IL10A; Interleukin 10… |
| Name | OCH |
|---|---|
| CAS | 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12392968 | Van Och FM, Van Loveren H, De Jong WH, Vandebriel RJ: Cytokine production induced by low-molecular-weight chemicals as a function of the stimulation index in a modified local lymph node assay: an approach to discriminate contact sensitizers from respiratory sensitizers. Toxicol Appl Pharmacol. 2002 Oct 1;184(1):46-56. From the estimated concentrations, IFN-gamma, IL-4, and IL-10 production as a function of stimulation indices were plotted. |
2(0,0,0,2) | Details |
| 14730629 | Chiba A, Oki S, Miyamoto K, Hashimoto H, Yamamura T, Miyake S: Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a -truncated analog of alpha-galactosylceramide. Arthritis Rheum. 2004 Jan;50(1):305-13. Neutralization of interleukin-4 (IL-4) or IL-10 with monoclonal antibodies abolished disease protection by OCH, indicating a critical role for these cytokines. |
1(0,0,0,1) | Details |
| 18698251 | Haeryfar SM, Lan Z, Leon-Ponte M, Duffy KR, Ge W, Liu W, Mele T, Garcia B, Wang H: Prolongation of cardiac allograft survival by rapamycin and the invariant natural killer T cell glycolipid agonist OCH. Transplantation. 2008 Aug 15;86(3):460-8. These were accompanied by elevated intragraft mRNA levels of interleukin (IL)-4, and to a lesser extent IL-10 and IL-13, and high transcript levels of Valpha14-Jalpha18 T-cell receptor gene segment. |
1(0,0,0,1) | Details |
| 19244550 | Mollinedo F, Gajate C, Morales AI, del Canto-Janez E, Justies N, Collia F, Rivas JV, Modolell M, Iglesias A: Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis. J Pharmacol Exp Ther. 2009 May;329(2):439-49. Epub 2009 Feb 25. Edelfosine enhanced lipopolysaccharide-induced expression of anti-inflammatory interleukin-10 in mouse macrophages. |
1(0,0,0,1) | Details |
| 15571923 | Mizuno M, Masumura M, Tomi C, Chiba A, Oki S, Yamamura T, Miyake S: Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice. J Autoimmun. 2004 Dec;23(4):293-300. OCH-mediated suppression of diabetes is associated with Th2 bias of anti-islet antigen response and increased IL-10 producing cells among islet-infiltrating leukocytes. |
1(0,0,0,1) | Details |