| Name | 5 HT transporter |
|---|---|
| Synonyms | Sodium dependent serotonin transporter; OCD1; 5 hydroxytryptamine transporter; 5HT transporter; 5HTT; HTT; OCD 1; SERT… |
| Name | OCH |
|---|---|
| CAS | 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18995929 | Herold F, Chodkowski A, Izbicki L, Krol M, Kleps J, Turlo J, Nowak G, Stachowicz K, Dybala M, Siwek A: Novel 4-aryl-pyrido [1,2-c] pyrimidines with dual SSRI and 5-HT1A activity, part 1. Eur J Med Chem. 2009 Apr;44(4):1710-7. Epub 2008 Sep 30. They were characterized (i) in vitro by binding to 5-HT (1A) receptors and 5-HT transporter proteins in rat brain cortex membranes and (ii) in vivo in the mouse by induced hypothermia and forced swimming models for antagonist/agonist activity against the 5-HT (1A) autoreceptors and postsynaptic 5-HT (1A) receptors, respectively. In contrast, the presence of a 5-methoxy-3-(4-piperidyl)-1H- residue as well as -Cl or -OCH (3) substituents at the para position markedly reduced the receptor affinity. |
1(0,0,0,1) | Details |
| 19665823 | Herold F, Izbicki L, Chodkowski A, Dawidowski M, Krol M, Kleps J, Turlo J, Wolska I, Nowak G, Stachowicz K, Dybala M, Siwek A, Nowak M, Pieniazek E, Jaronczyk M, Sylte I, Mazurek AP: Novel 4-aryl-pyrido [1,2-c] pyrimidines with dual SSRI and 5-HT1A activity: part 2. Eur J Med Chem. 2009 Nov;44(11):4702-15. Epub 2009 Jul 16. In vitro binding tests were performed to determine the affinity of the compounds for the 5-HT (1A) receptor and serotonin transporter (SERT) proteins in the rat brain cortex. |
3(0,0,0,3) | Details |