Protein Information

Name protein kinase C (protein family or complex)
Synonyms Protein kinase C; PKC

Compound Information

Name OCH
CAS 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one

Reference List

PubMed Abstract RScore(About this table)
16243962 Braverman AS, Doumanian LR, Ruggieri MR Sr: M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. J Pharmacol Exp Ther. 2006 Feb;316(2):875-80. Epub 2005 Oct 21.


Inhibition of PKC with chelerythrine increases darifenacin affinity, whereas inhibition of rho kinase, PKA, PKG, and protein kinase C (PKC) with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine.2HCl (H7) reduces the carbachol potency while increasing darifenacin affinity.
1(0,0,0,1) Details
17142672 Lacchini AH, Davies AJ, Mackintosh D, Walker AJ: Beta-1, 3-glucan modulates PKC signalling in Lymnaea stagnalis defence cells: a role for PKC in H2O2 production and downstream ERK activation. J Exp Biol. 2006 Dec;209(Pt 24):4829-40.


Haemocytes from the gastropod snail Lymnaea stagnalis (Linnaeus) were used as a model to characterize protein kinase C (PKC) signalling events in molluscan defence cells.
1(0,0,0,1) Details
18067888 McNally AK, Macewan SR, Anderson JM: Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta. Exp Mol Pathol. 2008 Feb;84(1):37-45. Epub 2007 Nov 9.

2(0,0,0,2) Details
20045694 Almeida-Amaral EE, Cardoso VC, Francioli FG, Meyer-Fernandes JR: Leishmania amazonensis: heme stimulates (Na (+)+K (+)) ATPase activity via phosphatidylinositol-specific phospholipase C/protein kinase C-like (PI-PLC/PKC) signaling pathways. Exp Parasitol. 2010 Apr;124(4):436-41. Epub 2010 Jan 4.

2(0,0,0,2) Details
18072286 Weng JY, Hsu TT, Sun SH: Functional characterization of P2Y1 versus P2X receptors in RBA-2 astrocytes: elucidate the roles of ATP release and protein kinase C. J Cell Biochem. 2008 May 15;104(2):554-67.

2(0,0,0,2) Details
16243961 Braverman AS, Tibb AS, Ruggieri MR Sr: M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. J Pharmacol Exp Ther. 2006 Feb;316(2):869-74. Epub 2005 Oct 21.


Inhibition of protein kinase C (PKC) with chelerythrine increases darifenacin affinity, whereas inhibition of rho kinase, PKA, PKG, and PKC with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine.2HCl (H7) reduces the carbachol maximum and carbachol potency while increasing darifenacin affinity.
1(0,0,0,1) Details
10679516 Ito T, Kozawa O, Tanabe K, Niwa M, Matsuno H, Sakai N, Ito H, Kato K, Uematsu T: p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells. Hypertension. 2000 Feb;35(2):673-8.


We previously showed that arginine vasopressin (AVP) stimulates heat shock protein 27 (HSP27) induction through protein kinase C activation in aortic smooth muscle A10 cells.
1(0,0,0,1) Details
9055074 Neiman AM, Mhaiskar V, Manus V, Galibert F, Dean N: Saccharomyces cerevisiae HOC1, a suppressor of pkc1, encodes a putative glycosyltransferase. Genetics. 1997 Mar;145(3):637-45.

The Saccharomyces cerevisiae gene PKC1 encodes a protein kinase C isozyme that regulates cell wall synthesis.
The HOC1 gene (Homologous to OCH1) is predicted to encode a type II integral membrane protein that strongly resembles Och 1p, an alpha-1,6-mannosyltransferase.
1(0,0,0,1) Details
19961846 Nakamura K, Yokotani K: Presynaptic BK type Ca (2+)-activated K (+) channels are involved in prostanoid TP receptor-mediated inhibition of noradrenaline release from the rat gastric sympathetic nerves. Eur J Pharmacol. 2010 Mar 10;629(1-3):111-7. Epub 2009 Dec 2.


Prostanoid TP receptor has been shown to activate phospholipase C (PLC), which catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-triphosphate (IP (3)) and diacylglycerol; IP (3) triggers the release of Ca (2+) from intracellular stores and diacylglycerol activates protein kinase C.
1(0,0,0,1) Details