Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name 2-phenylphenol
CAS [1,1′-biphenyl]-2-ol

Reference List

PubMed Abstract RScore(About this table)
2130942 Inoue S, Yamamoto K, Kawanishi S: DNA damage induced by metabolites of o-phenylphenol in the presence of copper (II) ion. Chem Res Toxicol. 1990 Mar-Apr;3(2):144-9.


Catalase, methionine, and methional inhibited the DNA damage completely, whereas mannitol, sodium formate, ethanol, tert-butyl alcohol, and superoxide dismutase did not. 2,5-Dihydroxybiphenyl plus Cu (II) frequently induced a piperidine-labile site at thymine and guanine residues.
2(0,0,0,2) Details
7517511 Tayama S, Nakagawa Y: Effect of scavengers of active oxygen species on cell damage caused in CHO-K1 cells by phenylhydroquinone, an o-phenylphenol metabolite. Mutat Res. 1994 Jul;324(3):121-31.


Mannitol (50 mM), a scavenger of hydroxyl radical (OH.), was ineffective and superoxide dismutase (SOD, 150 U/ml), a scavenger of O2-., or SOD plus catalase rather intensified the toxicity as did aminotriazole (20 mM), an inhibitor of catalase.
1(0,0,0,1) Details
17251053 Tani S, Yonezawa Y, Morisawa S, Nishioka H: Development of a new E. coli strain to detect oxidative mutation and its application to the fungicide o-phenylphenol and its metabolites. Mutat Res. 2007 Apr 2;628(2):123-8. Epub 2006 Dec 27.


However, in Escherichia coli (E. coli), ROS are eliminated by enzymes such as superoxide dismutase and catalase, which are coded by sodAB and katEG genes.
1(0,0,0,1) Details
2171789 Nagai F, Ushiyama K, Satoh K, Kano I: DNA cleavage by phenylhydroquinone: the major metabolite of a fungicide o-phenylphenol. Chem Biol Interact. 1990;76(2):163-79.


The DNA cleavage by PHQ was inhibited by superoxide dismutase (SOD), catalase and several oxygen radical scavengers such as polyethylene glycol, tert-butanol, dimethyl sulfoxide, sodium azide, sodium benzoate, bovine serum albumin and methionine.
1(0,0,0,1) Details