| 15214082 |
Rayabarapu DK, Chang HT, Cheng CH: Synthesis of phthalide derivatives using nickel-catalyzed cyclization of o-haloesters with aldehydes. Chemistry. 2004 Jun 21;10(12):2991-6.
A series of substituted aromatic and aliphatic aldehydes (2 b, 4-MeC (6) H (4) CHO; 2 c, 4-MeOC (6) H (4) CHO; 2 d, 3-MeOC (6) H (4) CHO; 2 e, 2-MeOC (6) H (4) CHO; 2 f, 4-CNC (6) H (4) CHO; 2 g, 4-(Me)(3) CC (6) H (4) CHO; 2 h, 4-C (6) H (5) C (6) H (4) CHO; 2 i, 4-ClC (6) H (4) CHO; 2 j, 4-CF (3) C (6) H (4) CHO; 2 k, CH (3)(CH (2))(5) CHO; 2 l, CH (3)(CH (2))(2) CHO) also underwent cyclization with o-bromobenzoate (1 b) producing the corresponding phthalide derivatives in moderate to excellent yields and with high chemoselectivity. |
31(0,1,1,1) |
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