Protein Information

Name estrogen receptor
Synonyms ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA…

Compound Information

Name tolclofos-methyl
CAS

Reference List

PubMed Abstract RScore(About this table)
16781191 Manabe M, Kanda S, Fukunaga K, Tsubura A, Nishiyama T: Evaluation of the estrogenic activities of some pesticides and their combinations using MtT/Se cell proliferation assay. Int J Hyg Environ Health. 2006 Sep;209(5):413-21. Epub 2006 Jun 15.

To evaluate MtT/Se cells we went down to the molecular level of estrogen receptor (ER)-alpha and ER-beta expression.
It was found that diazinon, tolclofos-methyl, pyriproxyfen, prothiofos and thiabendazole had estrogenic activity.
3(0,0,0,3) Details
11884232 Andersen HR, Vinggaard AM, Rasmussen TH, Gjermandsen IM, Bonefeld-Jorgensen EC: Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro. Toxicol Appl Pharmacol. 2002 Feb 15;179(1):1-12.

In addition, chlorpyrifos, deltamethrin, tolclofos-methyl, and tribenuron-methyl induced weak responses in one or both estrogenicity assays.
Twenty-four pesticides were tested for interactions with the estrogen receptor (ER) and the androgen receptor (AR) in transactivation assays.
1(0,0,0,1) Details
16219411 Bonefeld-Jorgensen EC, Grunfeld HT, Gjermandsen IM: Effect of pesticides on estrogen receptor transactivation in vitro: a comparison of stable transfected MVLN and transient transfected MCF-7 cells. Mol Cell Endocrinol. 2005 Dec 1;244(1-2):20-30. Epub 2005 Oct 10.

1(0,0,0,1) Details