| Name | H:quinone oxidoreductase |
|---|---|
| Synonyms | Diaphorase; DHQU; DIA 4; DIA4; DT diaphorase; DTD; Diaphorase (NADH/NADPH); Diaphorase (NADH/NADPH) (cytochrome b 5 reductase)… |
| Name | ethoxyquin |
|---|---|
| CAS | 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16045903 | Munday R, Smith BL, Munday CM: Effect of inducers of DT-diaphorase on the haemolytic activity and nephrotoxicity of 2-amino-1,4-naphthoquinone in rats. Chem Biol Interact. 2005 Aug 15;155(3):140-7. |
6(0,0,0,6) | Details |
| 10654840 | Munday R, Smith BL, Munday CM: Effect of inducers of DT-diaphorase on the toxicity of 2-methyl- and 2--1,4-naphthoquinone to rats. Chem Biol Interact. 1999 Dec 15;123(3):219-37. Rats were dosed with BHA, butylated hydroxytoluene (BHT), ethoxyquin (EQ), dimethyl (DMF) or disulfiram (DIS) and then challenged with a toxic dose of the naphthoquinones. |
5(0,0,0,5) | Details |
| 11309284 | McMahon M, Itoh K, Yamamoto M, Chanas SA, Henderson CJ, McLellan LI, Wolf CR, Cavin C, Hayes JD: The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and biosynthetic enzymes. Cancer Res. 2001 Apr 15;61(8):3299-307. Both Nrf2-/- and Nrf2+/+ mice were fed a control diet or one supplemented with either synthetic cancer chemopreventive agents [butylated hydroxyanisole (BHA), ethoxyquin (EQ), or oltipraz] or phytochemicals cafestol and kahweol (CMRN), or alpha-angelicalactone]. The constitutive level of NAD (P) H:quinone oxidoreductase (NQO) and glutathione S-transferase (GST) enzyme activities in cytosols from small intestine was typically found to be between 30% and 70% lower in samples prepared from Nrf2 mutant mice fed a control diet than in equivalent samples from Nrf2+/+ mice. |
3(0,0,0,3) | Details |
| 10706111 | Kelly VP, Ellis EM, Manson MM, Chanas SA, Moffat GJ, McLeod R, Judah DJ, Neal GE, Hayes JD: Chemoprevention of hepatocarcinogenesis by a natural benzopyrone that is a potent inducer of -aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD (P) H:quinone oxidoreductase in rat liver. Cancer Res. 2000 Feb 15;60(4):957-69. Treatment with either phytochemicals [benzyl isothiocyanate, (CMRN), or or synthetic antioxidants and other drugs (butylated hydroxyanisole, diethyl ethoxyquin, beta-naphthoflavone, oltipraz, phenobarbital, or trans-stilbene oxide) has been found to increase hepatic aldo-keto reductase activity toward -dialdehyde and glutathione S-transferase (GST) activity toward -8,9-epoxide in both male and female rats. |
2(0,0,0,2) | Details |
| 15919853 | Cheng X, Maher J, Dieter MZ, Klaassen CD: Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug Metab Dispos. 2005 Sep;33(9):1276-82. Epub 2005 May 26. Nrf2 activators (oltipraz, ethoxyquin, and butylated hydroxyanisole) down-regulated Oatp1a1 but up-regulated Oatp2b1 mRNA expression. All chemicals increased the expression of their well characterized target drug-metabolizing enzymes: AhR ligands increased Cyp1A1, CAR activators increased Cyp2B10, PXR ligands increased Cyp3A11, PPARalpha ligands increased Cyp4A14, and Nrf2 activators induced NAD (P) H:quinone oxidoreductase 1. |
1(0,0,0,1) | Details |
| 19158375 | Sakamoto K, Iwasaki K, Sugiyama H, Tsuji Y: Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications. Mol Biol Cell. 2009 Mar;20(6):1606-17. Epub 2009 Jan 21. The PI3K-dependent ferritin H induction was observed by treatment with other ARE-activating agents ethoxyquin and hemin. Consistently, PTEN restoration in Jurkat cells inhibited t-BHQ-mediated expression of ferritin H and another ARE-regulated gene NAD (P) H:quinone oxidoreductase 1. |
1(0,0,0,1) | Details |
| 7482539 | Buetler TM, Gallagher EP, Wang C, Stahl DL, Hayes JD, Eaton DL: Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz. Toxicol Appl Pharmacol. 1995 Nov;135(1):45-57. In this study, rats were treated with the monofunctional inducers tert-butylated hydroxyanisole, ethoxyquin, and oltipraz to study the inducibility of individual glutathione S-transferase isozymes, (H):quinone oxidoreductase, gamma-glutamylcysteine synthetase, UDP-glucuronosyl transferase, and cytochrome P450 enzymes. |
7(0,0,1,2) | Details |