| Name | glutathione S transferases |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | ethoxyquin |
|---|---|
| CAS | 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8923030 | Hayes JD, McLeod R, Ellis EM, Pulford DJ, Ireland LS, McLellan LI, Judah DJ, Manson MM, Neal GE: Regulation of glutathione S-transferases and aldehyde reductase by chemoprotectors: studies of mechanisms responsible for inducible resistance to IARC Sci Publ. 1996;(139):175-87. Two detoxification enzymes that mediate ethoxyquin-induced chemoprotection against have been identified by protein purification: a glutathione S-transferase (GST) Yc2 subunit with at least 100-fold greater activity towards -8,9-epoxide than previously studied transferases, and a unique aldehyde reductase with activity towards the dialdehydic form of -8,9-dihydrodiol. |
32(0,1,1,2) | Details |
| 2873884 | Kensler TW, Egner PA, Davidson NE, Roebuck BD, Pikul A, Groopman JD: Modulation of aflatoxin metabolism, aflatoxin-N7- formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases. Cancer Res. 1986 Aug;46(8):3924-31. |
32(0,1,1,2) | Details |
| 9328168 | Manson MM, Ball HW, Barrett MC, Clark HL, Judah DJ, Williamson G, Neal GE: Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and metabolism. Carcinogenesis. 1997 Sep;18(9):1729-38. Particularly because of their ability to induce the detoxifying activities of glutathione S-transferase Yc2 and aldehyde reductase, butylated hydroxytoluene, ethoxyquin, oltipraz, phenethyl isothiocyanate and sinigrin will be effective blocking agents in rodents, if administered prior to |
32(0,1,1,2) | Details |
| 6822548 | Pearson WR, Windle JJ, Morrow JF, Benson AM, Talalay P: Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. J Biol Chem. 1983 Feb 10;258(3):2052-62. Ethoxyquin (1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline) and disulfiram [bis (diethyldithiocarbamyl) disulfide] also enhance the activities of glutathione S-transferases and certain other enzymes. |
13(0,0,1,8) | Details |
| 2565179 | Makary M, Kim HL, Safe S, Womack J, Ivie GW: Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride. Comp Biochem Physiol C. 1989;92(2):171-4. |
12(0,0,2,2) | Details |
| 1953636 | Hayes JD, Judah DJ, McLellan LI, Kerr LA, Peacock SD, Neal GE: Ethoxyquin-induced resistance to in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for -8,9-epoxide. Biochem J. 1991 Oct 15;279 ( Pt 2):385-98. |
12(0,0,2,2) | Details |
| 8399318 | Derbel M, Igarashi T, Satoh T: Differential induction of glutathione S-transferase subunits by phenobarbital, 3-methylcholanthrene and ethoxyquin in rat liver and kidney. Biochim Biophys Acta. 1993 Oct 3;1158(2):175-80. |
12(0,0,2,2) | Details |
| 11399793 | Henson KL, Stauffer G, Gallagher EP: Induction of glutathione S-transferase activity and protein expression in brown bullhead (Ameiurus nebulosus) liver by ethoxyquin. Toxicol Sci. 2001 Jul;62(1):54-60. |
7(0,0,1,2) | Details |
| 3630203 | Stewart J, Boston CM: Effect of pretreatment with 3-methylcholanthrene and several phenolic antioxidants on glutathione S-transferase activity in various tissues of female Sprague-Dawley rats. Xenobiotica. 1987 Jun;17(6):679-84. Treatment of female Sprague-Dawley rats with 3-methylcholanthrene, butylated hydroxyanisole, ethoxyquin, propyl or methylcholanthrene plus butylated hydroxyanisole was undertaken to determine the effects on glutathione S-transferase activity in liver, small intestine, lung and kidney. 2. |
7(0,0,1,2) | Details |
| 8198522 | McLellan LI, Judah DJ, Neal GE, Hayes JD: Regulation of -metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors. Biochem J. 1994 May 15;300 ( Pt 1):117-24. We have previously shown that treatment of rats with the chemoprotector ethoxyquin (EQ) results in a marked increase in expression of the Alpha-class glutathione S-transferase (GST) Yc2 subunit which has high activity towards -8,9-epoxide [Hayes, Judah, McLellan, Kerr, Peacock and Neal (1991) Biochem. |
7(0,0,1,2) | Details |
| 7482539 | Buetler TM, Gallagher EP, Wang C, Stahl DL, Hayes JD, Eaton DL: Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz. Toxicol Appl Pharmacol. 1995 Nov;135(1):45-57. In this study, rats were treated with the monofunctional inducers tert-butylated hydroxyanisole, ethoxyquin, and oltipraz to study the inducibility of individual glutathione S-transferase isozymes, (H):quinone oxidoreductase, gamma-glutamylcysteine synthetase, UDP-glucuronosyl transferase, and cytochrome P450 enzymes. |
6(0,0,1,1) | Details |
| 9679543 | Hayes JD, Pulford DJ, Ellis EM, McLeod R, James RF, Seidegard J, Mosialou E, Jernstrom B, Neal GE: Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to Chem Biol Interact. 1998 Apr 24;111-112:51-67. The glutathione S-transferase (GST) isoenzymes in rat liver that contribute to ethoxyquin-induced chemoprotection against have been identified by protein purification. |
6(0,0,1,1) | Details |
| 10816095 | Hayes JD, Chanas SA, Henderson CJ, McMahon M, Sun C, Moffat GJ, Wolf CR, Yamamoto M: The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans. 2000 Feb;28(2):33-41. |
6(0,0,1,1) | Details |
| 2861889 | Thamavit W, Tatematsu M, Ogiso T, Mera Y, Tsuda H, Ito N: Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase. Cancer Lett. 1985 Jul;27(3):295-303. |
6(0,0,1,1) | Details |
| 10706111 | Kelly VP, Ellis EM, Manson MM, Chanas SA, Moffat GJ, McLeod R, Judah DJ, Neal GE, Hayes JD: Chemoprevention of hepatocarcinogenesis by a natural benzopyrone that is a potent inducer of -aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD (P) H:quinone oxidoreductase in rat liver. Cancer Res. 2000 Feb 15;60(4):957-69. Treatment with either phytochemicals [benzyl isothiocyanate, (CMRN), or or synthetic antioxidants and other drugs (butylated hydroxyanisole, diethyl ethoxyquin, beta-naphthoflavone, oltipraz, phenobarbital, or trans-stilbene oxide) has been found to increase hepatic aldo-keto reductase activity toward -dialdehyde and glutathione S-transferase (GST) activity toward -8,9-epoxide in both male and female rats. |
6(0,0,1,1) | Details |
| 6487318 | Awasthi YC, Singh SV, Goel SK, Reddy JK: Irreversible inhibition of hepatic glutathione S-transferase by ciprofibrate, a peroxisome proliferator. Biochem Biophys Res Commun. 1984 Sep 28;123(3):1012-8. |
4(0,0,0,4) | Details |
| 8484743 | Parola M, Biocca ME, Leonarduzzi G, Albano E, Dianzani MU, Gilmore KS, Meyer DJ, Ketterer B, Slater TF, Cheeseman KH: Constitutive and inducible profile of glutathione S-transferase subunits in biliary epithelial cells and hepatocytes isolated from rat liver. Biochem J. 1993 Apr 15;291 ( Pt 2):641-7. For the first time, the effects of the inducing agents phenobarbitone (PB), beta-naphthoflavone (beta-NF) and ethoxyquin (EQ) have been characterized in a comprehensive and quantitative manner in both cell types. |
2(0,0,0,2) | Details |
| 1637297 | Hayes JD, Judah DJ, Neal GE, Nguyen T: Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for -8,9-epoxide. Biochem J. 1992 Jul 1;285 ( Pt 1):173-80. Comparison of the deduced amino acid sequence of the mouse Yc polypeptide with the primary structures of the rat Alpha-class GST enzymes revealed that it is more closely related to the ethoxyquin-induced rat liver Yc2 subunit than to the constitutively expressed rat liver Yc1 subunit. |
2(0,0,0,2) | Details |
| 2895690 | Tsuda H, Moore MA, Asamoto M, Inoue T, Ito N, Satoh K, Ichihara A, Nakamura T, Amelizad Z, Oesch F: Effect of modifying agents on the phenotypic expression of cytochrome P-450, glutathione S-transferase molecular forms, microsomal epoxide hydrolase, glucose-6-phosphate dehydrogenase and gamma-glutamyltranspeptidase in rat liver preneoplastic lesions. Carcinogenesis. 1988 Apr;9(4):547-54. |
2(0,0,0,2) | Details |
| 1336490 | Tsuda H, Ozaki K, Uwagawa S, Yamaguchi S, Hakoi K, Aoki T, Kato T, Sato K, Ito N: Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats. Jpn J Cancer Res. 1992 Nov;83(11):1154-65. Degree of conformity of marker enzymes such as glutathione S-transferase placental form (GST-P), glucose-6-phosphate dehydrogenase (G6PD), glucose-6-phosphatase, triphosphatase and gamma-glutamyltranspeptidase was compared with levels of 5-bromo-2- labeling. After initiation with diethylnitrosamine, rats were administered the hepatopromoter phenobarbital (PB, 0.05%), the antioxidant ethoxyquin (EQ, 0.5%), or a peroxisome proliferator, clofibrate (CF, 1.0%) or di (2-ethylhexyl)- (0.3%) and killed at week 16 or 32. |
1(0,0,0,1) | Details |
| 11309284 | McMahon M, Itoh K, Yamamoto M, Chanas SA, Henderson CJ, McLellan LI, Wolf CR, Cavin C, Hayes JD: The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and biosynthetic enzymes. Cancer Res. 2001 Apr 15;61(8):3299-307. Both Nrf2-/- and Nrf2+/+ mice were fed a control diet or one supplemented with either synthetic cancer chemopreventive agents [butylated hydroxyanisole (BHA), ethoxyquin (EQ), or oltipraz] or phytochemicals cafestol and kahweol (CMRN), or alpha-angelicalactone]. The constitutive level of NAD (P) H:quinone oxidoreductase (NQO) and glutathione S-transferase (GST) enzyme activities in cytosols from small intestine was typically found to be between 30% and 70% lower in samples prepared from Nrf2 mutant mice fed a control diet than in equivalent samples from Nrf2+/+ mice. |
1(0,0,0,1) | Details |
| 9202746 | Huber WW, McDaniel LP, Kaderlik KR, Teitel CH, Lang NP, Kadlubar FF: Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) in the rat. Mutat Res. 1997 May 12;376(1-2):115-22. The 16 treatments (Oltipraz, benzylisothiocyanate, diallyl sulfide, garlic powder, ethoxyquin, butylated hydroxyanisole, alpha-angelicalactone, kahweol/cafestol palmitates, green tea, black tea, tannic acid, amylase-resistant starch, and physical exercise) comprised -containing compounds, antioxidants, flavonoids, diterpenes, polyphenols, high dietary fiber, etc. Preliminary studies on their mechanism of action indicated that only kahweol:cafestol caused a substantial induction of glutathione S-transferase isozymes (GSTs) that are thought to be important in the detoxification of PhIP. |
1(0,0,0,1) | Details |
| 11023540 | Shepherd AG, Manson MM, Ball HW, McLellan LI: Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B (1)-induced preneoplasia. Carcinogenesis. 2000 Oct;21(10):1827-34. Treatment with the synthetic antioxidant ethoxyquin or the classic inducer phenobarbital caused < 2-fold induction of GLCL activity in rat liver, which was not found to be significant. The glutathione S-transferase (GST) subunits A1, A3, A4, A5, P1 and M1 were all found to be inducible in rat liver by most of the agents. |
1(0,0,0,1) | Details |
| 16790489 | Berdikova Bohne VJ, Hamre K, Arukwe A: Hepatic biotransformation and metabolite profile during a 2-week depuration period in Atlantic salmon fed graded levels of the synthetic antioxidant, ethoxyquin. Toxicol Sci. 2006 Sep;93(1):11-21. Epub 2006 Jun 21. Consumption of dietary EQ produced the expression of CYP3A, glutathione S-transferase (GST), and glucuronosyl-transferase (UDPGT) mRNA during the depuration period. |
1(0,0,0,1) | Details |
| 8042848 | Eaton DL, Gallagher EP: Mechanisms of aflatoxin carcinogenesis. Annu Rev Pharmacol Toxicol. 1994;34:135-72. Detoxification of AFB-8,9-epoxide by a specific alpha class glutathione S-transferase is an important protective mechanism in mice, and it accounts for the resistance of this species to the carcinogenic effects of AFB. This particular form of GST is expressed constitutively only at low levels in rats, but it is inducible by antioxidants such as ethoxyquin, and it accounts for much of the chemoprotective effects of a variety of substances, including natural dietary components that putatively act via an "antioxidant response element" (ARE). |
1(0,0,0,1) | Details |
| 2887284 | Mandel HG, Manson MM, Judah DJ, Simpson JL, Green JA, Forrester LM, Wolf CR, Neal GE: Metabolic basis for the protective effect of the antioxidant ethoxyquin on hepatocarcinogenesis in the rat. Cancer Res. 1987 Oct 1;47(19):5218-23. EQ increased the glutathione S-transferase activity of the liver cytosol fractions as assessed with the model substrate 1-chloro-2,4-dinitrobenzene. |
1(0,0,0,1) | Details |
| 8395332 | Hayes JD, Judah DJ, Neal GE: Resistance to is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic -containing metabolite of the toxin. Cancer Res. 1993 Sep 1;53(17):3887-94. The relative importance of -AR and the glutathione-S-transferase Yc2 subunit in conferring resistance to is discussed. Fischer 344 rats readily develop liver cancer when exposed to but dietary administration of the antioxidant ethoxyquin (EQ) provides protection against hepatocarcinogenesis. |
1(0,0,0,1) | Details |
| 11448651 | Guyonnet D, Belloir C, Suschetet M, Siess MH, Le Bon AM: Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction. Mutat Res. 2001 Aug 22;495(1-2):135-45. Interestingly, DADS appeared to be as effective as ethoxyquin, a model inducer of phase II enzymes, in both inducing phase II enzymes and inhibiting the mutagenicity of carcinogens. DADS strongly increased all the phase II enzymes activities examined, i.e. total glutathione S-transferase (GST) activity, mu GST activity, quinone reductase (QR) activity and epoxide hydrolase (EH) activity. |
1(0,0,0,1) | Details |
| 363262 | Benson AM, Batzinger RP, Ou SY, Bueding E, Cha YN, Talalay P: Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo (a) pyrene by dietary antioxidants. Cancer Res. 1978 Dec;38(12):4486-95. |
1(0,0,0,1) | Details |
| 3924431 | Kensler TW, Egner PA, Trush MA, Bueding E, Groopman JD: Modification of binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione. Carcinogenesis. 1985 May;6(5):759-63. An excellent correlation (r = 0.95) was observed between the degree of inhibition of DNA binding by and the induction of hepatic glutathione S-transferase activities by the four antioxidants. |
1(0,0,0,1) | Details |
| 6678746 | Cha YN, Heine HS, Ansher S: Comparative effects of dietary administration of antioxidants and inducers on the activities of several hepatic enzymes in mice. Drug Nutr Interact. 1983;2(1):35-45. Feeding mice with anticarcinogenic antioxidants, 2 (3)-tert-butyl-4-hydroxyanisole (BHA), ethoxyquin (EQ), disulfiram (DSF), and selenite (SE) resulted in selective changes in hepatic microsomal mixed function oxidases and in other enzymatic activities which were different from those obtained by feeding phenobarbital (PB), 3-methyl cholanthrene (MC), and Aroclor (ARO). |
0(0,0,0,0) | Details |