| Name | aldehyde reductase |
|---|---|
| Synonyms | ADR; ALDR 1; ALDR1; Aldehyde reductase; AKR1B1; AKR1B1 protein; AR; Aldehyde reductase 1… |
| Name | ethoxyquin |
|---|---|
| CAS | 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8234296 | Ellis EM, Judah DJ, Neal GE, Hayes JD: An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes defines a subfamily of aldo-keto reductases. Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10350-4. |
39(0,1,2,4) | Details |
| 8923030 | Hayes JD, McLeod R, Ellis EM, Pulford DJ, Ireland LS, McLellan LI, Judah DJ, Manson MM, Neal GE: Regulation of glutathione S-transferases and aldehyde reductase by chemoprotectors: studies of mechanisms responsible for inducible resistance to IARC Sci Publ. 1996;(139):175-87. Two detoxification enzymes that mediate ethoxyquin-induced chemoprotection against have been identified by protein purification: a glutathione S-transferase (GST) Yc2 subunit with at least 100-fold greater activity towards -8,9-epoxide than previously studied transferases, and a unique aldehyde reductase with activity towards the dialdehydic form of -8,9-dihydrodiol. |
33(0,1,1,3) | Details |
| 9328168 | Manson MM, Ball HW, Barrett MC, Clark HL, Judah DJ, Williamson G, Neal GE: Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and metabolism. Carcinogenesis. 1997 Sep;18(9):1729-38. Particularly because of their ability to induce the detoxifying activities of glutathione S-transferase Yc2 and aldehyde reductase, butylated hydroxytoluene, ethoxyquin, oltipraz, phenethyl isothiocyanate and sinigrin will be effective blocking agents in rodents, if administered prior to |
32(0,1,1,2) | Details |
| 8503840 | Judah DJ, Hayes JD, Yang JC, Lian LY, Roberts GC, Farmer PB, Lamb JH, Neal GE: A novel aldehyde reductase with activity towards a metabolite of is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant. Biochem J. 1993 May 15;292 ( Pt 1):13-8. In contrast with fractions from control animals, an aldehyde reductase, which catalyses the reduction of -dihydrodiol, in the dialdehyde form at physiological pH values, to -dialcohol, is expressed in cytosolic fractions prepared from rat livers bearing pre-neoplastic lesions, or following treatment with the anti-oxidant ethoxyquin. |
32(0,1,1,2) | Details |
| 14667815 | Barski OA, Papusha VZ, Kunkel GR, Gabbay KH: Regulation of aldehyde reductase expression by STAF and CHOP. . Genomics. 2004 Jan;83(1):119-29. Transfection of the human promoter into ethoxyquin-treated mouse 3T3 cells induces a 3.5-fold increase in promoter activity and a CHOP-C/EBP band appears on gel shifts performed with the 5' probe from the human aldehyde reductase promoter. |
12(0,0,1,7) | Details |
| 9310340 | Jez JM, Flynn TG, Penning TM: A new nomenclature for the aldo-keto reductase superfamily. Biochem Pharmacol. 1997 Sep 15;54(6):639-47. Other families include the prokaryotic AKRs, the plant reductases, the Shaker channels, and the ethoxyquin-inducible aldehyde reductase. |
9(0,0,1,4) | Details |
| 10816434 | Kelly VP, Ireland LS, Ellis EM, Hayes JD: Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extrahepatic tissues. Biochem J. 2000 Jun 1;348 Pt 2:389-400. This novel enzyme is designated rat aflatoxin B (1) aldehyde reductase 2 (rAFAR2) and it characteristically migrates faster during SDS/PAGE than does the archetypal ethoxyquin-inducible rAFAR protein (now called rAFAR1). |
6(0,0,1,1) | Details |
| 9679543 | Hayes JD, Pulford DJ, Ellis EM, McLeod R, James RF, Seidegard J, Mosialou E, Jernstrom B, Neal GE: Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to Chem Biol Interact. 1998 Apr 24;111-112:51-67. In addition to GSTA5, we have identified a novel aflatoxin-aldehyde reductase (AFAR) that is similarly induced by ethoxyquin. |
6(0,0,1,1) | Details |
| 14676331 | Keightley JA, Shang L, Kinter M: Proteomic analysis of oxidative stress-resistant cells: a specific role for aldose reductase overexpression in cytoprotection. Mol Cell Proteomics. 2004 Feb;3(2):167-75. Epub 2003 Dec 15. Based on this observation, the role of AR in the resistant phenotype was investigated by using a combination of AR induction with ethoxyquin and AR inhibition with Alrestatin to test the cytotoxicity of two oxidation-derived aldehydes: acrolein and |
2(0,0,0,2) | Details |
| 10706111 | Kelly VP, Ellis EM, Manson MM, Chanas SA, Moffat GJ, McLeod R, Judah DJ, Neal GE, Hayes JD: Chemoprevention of hepatocarcinogenesis by a natural benzopyrone that is a potent inducer of -aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD (P) H:quinone oxidoreductase in rat liver. Cancer Res. 2000 Feb 15;60(4):957-69. Treatment with either phytochemicals [benzyl isothiocyanate, (CMRN), or or synthetic antioxidants and other drugs (butylated hydroxyanisole, diethyl ethoxyquin, beta-naphthoflavone, oltipraz, phenobarbital, or trans-stilbene oxide) has been found to increase hepatic aldo-keto reductase activity toward -dialdehyde and glutathione S-transferase (GST) activity toward -8,9-epoxide in both male and female rats. |
2(0,0,0,2) | Details |
| 9823300 | Praml C, Savelyeva L, Perri P, Schwab M: Cloning of the human -aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells. Cancer Res. 1998 Nov 15;58(22):5014-8. In rat liver, Afar is strongly inducible by the antioxidants ethoxyquin and butylated hydroxyanisole, which protect the rat against -induced liver tumorigenesis by detoxifying its genotoxic and cytotoxic dialdehyde. |
2(0,0,0,2) | Details |
| 8198522 | McLellan LI, Judah DJ, Neal GE, Hayes JD: Regulation of -metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors. Biochem J. 1994 May 15;300 ( Pt 1):117-24. We have previously shown that treatment of rats with the chemoprotector ethoxyquin (EQ) results in a marked increase in expression of the Alpha-class glutathione S-transferase (GST) Yc2 subunit which has high activity towards -8,9-epoxide [Hayes, Judah, McLellan, Kerr, Peacock and Neal (1991) Biochem. |
2(0,0,0,2) | Details |
| 11728387 | Grant A, Staffas L, Mancowitz L, Kelly VP, Manson MM, DePierre JW, Hayes JD, Ellis EM: Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility. Biochem Pharmacol. 2001 Dec 1;62(11):1511-9. However, AKR7A1 was inducible by the synthetic antioxidant ethoxyquin in liver, kidney, and small intestine, but not in the other tissues examined. |
1(0,0,0,1) | Details |
| 8395332 | Hayes JD, Judah DJ, Neal GE: Resistance to is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic -containing metabolite of the toxin. Cancer Res. 1993 Sep 1;53(17):3887-94. Therefore, this inducible enzyme has been designated -aldehyde reductase -AR). Fischer 344 rats readily develop liver cancer when exposed to but dietary administration of the antioxidant ethoxyquin (EQ) provides protection against hepatocarcinogenesis. |
1(0,0,0,1) | Details |