| Name | aldo keto reductase (protein family or complex) |
|---|---|
| Synonyms | aldo keto reductase; aldo keto reductases |
| Name | ethoxyquin |
|---|---|
| CAS | 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8234296 | Ellis EM, Judah DJ, Neal GE, Hayes JD: An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes defines a subfamily of aldo-keto reductases. Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10350-4. |
82(1,1,1,2) | Details |
| 10706111 | Kelly VP, Ellis EM, Manson MM, Chanas SA, Moffat GJ, McLeod R, Judah DJ, Neal GE, Hayes JD: Chemoprevention of hepatocarcinogenesis by a natural benzopyrone that is a potent inducer of -aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD (P) H:quinone oxidoreductase in rat liver. Cancer Res. 2000 Feb 15;60(4):957-69. Treatment with either phytochemicals [benzyl isothiocyanate, (CMRN), or or synthetic antioxidants and other drugs (butylated hydroxyanisole, diethyl ethoxyquin, beta-naphthoflavone, oltipraz, phenobarbital, or trans-stilbene oxide) has been found to increase hepatic aldo-keto reductase activity toward -dialdehyde and glutathione S-transferase (GST) activity toward -8,9-epoxide in both male and female rats. |
6(0,0,1,1) | Details |
| 9310340 | Jez JM, Flynn TG, Penning TM: A new nomenclature for the aldo-keto reductase superfamily. Biochem Pharmacol. 1997 Sep 15;54(6):639-47. Other families include the prokaryotic AKRs, the plant reductases, the Shaker channels, and the ethoxyquin-inducible aldehyde reductase. |
3(0,0,0,3) | Details |
| 19920056 | MacLeod AK, Kelly VP, Higgins LG, Kelleher MO, Price SA, Bigley AL, Betton GR, Hayes JD: Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants. Drug Metab Dispos. 2010 Feb;38(2):341-6. Epub 2009 Nov 17. Previous studies have shown that expression of AKR7A1 is induced in response to dietary administration of the phenolic antioxidants butylated hydroxyanisole and ethoxyquin. |
2(0,0,0,2) | Details |
| 12123834 | Hinshelwood A, McGarvie G, Ellis E: Characterisation of a novel mouse liver aldo-keto reductase AKR7A5. FEBS Lett. 2002 Jul 17;523(1-3):213-8. The protein is not inducible in the liver by dietary ethoxyquin. |
2(0,0,0,2) | Details |
| 8923030 | Hayes JD, McLeod R, Ellis EM, Pulford DJ, Ireland LS, McLellan LI, Judah DJ, Manson MM, Neal GE: Regulation of glutathione S-transferases and aldehyde reductase by chemoprotectors: studies of mechanisms responsible for inducible resistance to IARC Sci Publ. 1996;(139):175-87. A number of xenobiotics, including the synthetic antioxidant ethoxyquin, inhibit -induced hepatocarcinogenesis in the rat. Molecular cloning has revealed that the Yc2 subunit is a class alpha GST and that the aflatoxin-metabolizing aldehyde reductase (AFAR) is a distant member of the aldo-keto reductase superfamily. |
1(0,0,0,1) | Details |
| 11728387 | Grant A, Staffas L, Mancowitz L, Kelly VP, Manson MM, DePierre JW, Hayes JD, Ellis EM: Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility. Biochem Pharmacol. 2001 Dec 1;62(11):1511-9. The regulation of the aldo-keto reductase AKR7A1 was examined in the livers of male and female rats during development by using Western blots, and its contribution to carbonyl metabolism was assessed by using enzyme assays. However, AKR7A1 was inducible by the synthetic antioxidant ethoxyquin in liver, kidney, and small intestine, but not in the other tissues examined. |
1(0,0,0,1) | Details |
| 8395332 | Hayes JD, Judah DJ, Neal GE: Resistance to is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic -containing metabolite of the toxin. Cancer Res. 1993 Sep 1;53(17):3887-94. Fischer 344 rats readily develop liver cancer when exposed to but dietary administration of the antioxidant ethoxyquin (EQ) provides protection against hepatocarcinogenesis. |
1(0,0,0,1) | Details |